The chronic kidney disease–mineral and bone disorder (CKD–MBD) syndrome is an
extremely important complication of kidney diseases. Here we tested whether CKD–MBD …

Klotho knock-out mice are an important model for vascular calcification, which is associated
with chronic kidney disease. In chronic kidney disease, serum magnesium inversely …

Vascular calcification (VC) is highly prevalent in aging, diabetes mellitus, and chronic kidney
disease (CKD). VC is a strong predictor of cardiovascular morbidity and mortality in the CKD …

This chapter talks about pathophysiology of chronic kidney disease mineral bone disorder
(CKD‐MBD). It discusses the pathogenetic factors such as fibroblast growth factor 23 …

Chronic kidney disease (CKD) is a complex and multifactorial disease, and one of the most
prevalent worldwide. Chronic kidney disease–mineral bone disorders (CKD–MBD) with …

At the early stage of chronic kidney disease (CKD), the systemic mineral metabolism and
bone composition start to change. This alteration is known as chronic kidney disease …

Aging is associated with the development of both osteo-porosis and vascular disease, and
there is increasing evidence for a link between bone metabolism and the vasculature. 1 A …

Chronic Kidney Disease (CKD)–Mineral and Bone Disorder (CKD-MBD) is a complex
disease that is not completely understood. However, some factors secreted by the …

Klotho is a putative aging suppressor gene encoding a single-pass transmembrane co-
receptor that makes the fibroblast growth factor (FGF) receptor specific for FGF-23. In …

High concentrations of extracellular phosphate are toxic to cells. Impaired urinary phosphate
excretion increases serum phosphate level and induces a premature-ageing phenotype …