Protein-bound 3, 4-dihydroxyphenylalanine (PB-DOPA) is a major product of hydroxyl
radical attack on tyrosine residues of proteins. Levels of PB-DOPA in cells and tissues have …

Protein-bound 3, 4-dihydroxyphenylalanine (DOPA) can be generated in mammalian cells
by both controlled enzymatic pathways, and by uncontrolled radical reactions. Protein …

Levodopa (L‐dopa) is the most widely used agent for the symptomatic relief of Parkinson's
disease. There is concern that chronic L‐dopa treatment may be detrimental, with some …

Oxidized protein deposition and accumulation have been implicated in the aetiology of a
wide variety of age-related pathologies. Protein oxidation in vivo commonly results in the in …

We have previously reported the presence, in human midbrain, of an enzymatic activity
which catalyzes the formation of dopaminochrome from dopamine (DA) and hydrogen …

It is widely believed that hydroxyl radicals generatedin vivocontribute to damage to
macromolecules, such as proteins and DNA. We evaluated methodology based on the …

Cellular deposits of oxidized and aggregated proteins are hallmarks of a variety of age-
related disorders, but whether such proteins contribute to pathology is not well understood …

Publisher Summary This chapter describes the metabolism of dopamine (DA) and l-dopa in
human brain. l-DOPA treatment in Parkinson's disease can be regarded as a DA …

A consistent neurochemical abnormality in Parkinson's disease (PD) is degeneration of
dopaminergic neurons in substantia nigra, leading to a reduction of striatal dopamine (DA) …

Dopamine (DA) undergoes monoamine oxidase catalyzed oxidative deamination to 3, 4-
dihydroxyphenylacetaldehyde (DOPAL), which is metabolized primarily to 3, 4 …