For decades, fungi have been a source of US Food and Drug Administration–approved
natural products such as penicillin, cyclosporine, and the statins. Recent breakthroughs in …

Covering: up to 2014 Large scale fungal genome sequencing has revealed a multitude of
potential natural product biosynthetic pathways that remain uncharted. Here we describe …

Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

Fungal natural products include antibiotics such as the penicillins, antirejection drugs such
as cyclosporins and cholesterollowering drugs such as the statins. High productivity of these …

Recent published sequencing of fungal genomes has revealed that these microorganisms
have a surprisingly large number of secondary metabolite pathways that can serve as …

Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

Filamentous fungi have the capacity to produce a battery of natural products of often
unknown function, synthesized by complex metabolic pathways. Unfortunately, most of these …

Fungi are a prolific source of bioactive compounds, some of which have been developed as
essential medicines and life-enhancing drugs. Genome sequencing has revealed that fungi …

Microorganisms produce a wide range of natural products (NPs) with clinically and
agriculturally relevant biological activities. In bacteria and fungi, genes encoding successive …

Many Fungi have a well-developed secondary metabolism. The diversity of fungal species
and the diversification of biosynthetic gene clusters underscores a nearly limitless potential …