National and regional population-based registries are, provided diagnostic accuracy and full
coverage of the target population, indispensible tools for epidemiological research. Chronic …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of hematopoietic
stem cells. At the molecular level, the disorder results from t (9; 22)(q34; q11) reciprocal …

Chronic myeloid leukemia (CML) has been studied intensively for many years; yet its
treatment remains problematic and its biology remains elusive. In chronic phase, the …

The natural history of chronic myeloid leukemia (CML) progresses from a relatively benign
chronic phase into a fatal blast crisis, which resembles acute leukemia, but is incurable by …

Patients with splenomegaly and abnormally high leukocyte counts were first recognized in
France, Germany, and Scotland in the 1840s. The only well-documented therapy in the 19th …

Chronic myeloid leukaemia (CML) is caused by the product of the BCR-ABL oncogene,
located on the Philadelphia (Ph) chromosome. BCR-ABL is generated as a result of a …

The majority of patients with chronic‐phase (CP) chronic myeloid leukemia (CML) who are
treated with Bcr‐Abl tyrosine kinase inhibitors such as imatinib and dasatinib achieve …

Purpose. Chronic myeloid leukemia (CML), a hematopoietic stem cell cancer representing
15–20% of adult leukemias, is discussed. Epidemiology, staging biology, and monitoring …

Chronic myeloid leukemia (CML) has become a model in research and management among
malignant disorders. Since the discovery of the presence of a unique and constant …