Ultrasensitive UPLC-MS-MS method for the quantitation of etheno-DNA adducts in human urine

S Cui, H Li, S Wang, X Jiang, S Zhang… - International Journal of …, 2014 - mdpi.com
Etheno-DNA adducts are generated from the metabolism of exogenous carcinogens and
endogenous lipid peroxidation. We and others have previously reported that 1, N 6 …

New ultrasensitive 32P-postlabelling method for the analysis of 3,N4-etheno-2′-deoxycytidine in human urine

X Sun, A Karlsson, H Bartsch, J Nair - Biomarkers, 2006 - Taylor & Francis
Etheno–DNA adducts are generated from exogenous carcinogens such as vinyl chloride
and urethane and also from endogenous lipid peroxidation products such as trans-4 …

Ultrasensitive UPLC–MS/MS method for analysis of etheno-DNA adducts in human white blood cells

H Li, S Cui, S Wang, X Jiang, S Zhang… - Free Radical …, 2015 - Taylor & Francis
Etheno-DNA adducts are generated by interaction of cellular DNA with exogenous
environmental carcinogens and end products of lipid peroxidation. It has been determined …

Quantification of urinary etheno-DNA adducts by column-switching LC/APCI-MS/MS

PR Hillestrøm, A Weimann, HE Poulsen - … of the American Society for Mass …, 2006 - Springer
Lipid peroxidation induced etheno-DNA adducts are promutagenic and have been
suggested to play a causal role in the development of human cancers. Therefore, human …

Effect of gender and cigarette smoking on urinary excretion of etheno DNA adducts in humans measured by isotope dilution gas chromatography/mass spectrometry

HJC Chen, CF Kao - Toxicology letters, 2007 - Elsevier
Endogenous formation of the promutagenic DNA adducts 1, N6-ethenoadenine (ɛAde) and
3, N4-ethenocytosine (ɛCyt) has been considered as biomarkers originated from lipid …

Quantification of Urinary Excretion of 1,N6-Ethenoadenine, a Potential Biomarker of Lipid Peroxidation, in Humans by Stable Isotope Dilution Liquid Chromatography …

HJC Chen, CM Chang - Chemical research in toxicology, 2004 - ACS Publications
Etheno DNA adducts are promutagenic DNA lesions derived from exogenous as well as
endogenous sources. The levels of etheno adducts in tissue DNA are elevated in cancer …

Effect of Cigarette Smoking on Urinary 3,N4-Ethenocytosine Levels Measured by Gas Chromatography/Mass Spectrometry

HJC Chen, CL Hong, CF Wu, WL Chiu - Toxicological Sciences, 2003 - academic.oup.com
Etheno DNA adducts are DNA damages derived from exogenous carcinogens as well as
endogenous lipid peroxidation and oxidative stress. Elevated levels of etheno DNA adducts …

Urinary Excretion of 3,N4-Etheno-2'-deoxycytidine in Humans as a Biomarker of Oxidative Stress:  Association with Cigarette Smoking

HJC Chen, CF Wu, CL Hong… - Chemical research in …, 2004 - ACS Publications
Smokers are known to have elevated levels of lipid peroxidation, a form of oxidative stress.
Etheno DNA adduct formation can originate from endogenous lipid peroxidation or from …

Quantifying Etheno–DNA Adducts in Human Tissues, White Blood Cells, and Urine by Ultrasensitive 32P-Postlabeling and Immunohistochemistry

J Nair, UJ Nair, X Sun, Y Wang, K Arab… - … In Situ, Ex Vivo, and In …, 2011 - Springer
Exocyclic etheno–DNA adducts are formed by the reaction of lipid peroxidation products,
such as 4-hydroxy-2-nonenal (HNE) with DNA bases to yield 1, N 6-etheno-2 …

Simultaneous quantification of three lipid peroxidation-derived etheno adducts in human DNA by stable isotope dilution nanoflow liquid chromatography nanospray …

HJC Chen, GJ Lin, WP Lin - Analytical Chemistry, 2010 - ACS Publications
Etheno DNA adducts are promutagenic DNA lesions derived from exogenous industrial
chemicals, as well as endogenous sources including lipid peroxidation. Furthermore, levels …