Germinal centers (GCs) are essential structures of the humoral immune response, which
form in the periphery in response to T cell dependent antigens. During the GC reaction, B …

Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity
antibodies and are also the origin of most human B cell lymphomas. Recent progress has …

The immune system requires the production of high affinity antibodies of different subclasses
to accomplish its many effector functions. Specific steps in B-cell ontogeny that occur within …

Germinal centers (GCs) are transient microstructures formed within the follicles of secondary
lymphoid tissues in response to certain types of immunization and foreign pathogens. A …

Over the past several years, studies on normal and malignant B cells have provided new
insights into the unique physiology of the germinal centre (GC). In particular, advances in …

Germinal centers (GC) are sites of rapid B‐cell proliferation in response to certain types of
immunization. They arise in about 1 week and can persist for several months. In GC s, B …

The germinal center (GC) reaction is crucial for T cell-dependent immune responses and is
targeted by B cell lymphomagenesis. Here we analyzed the transcriptional changes that …

The germinal center (GC) reaction is a key process during an adaptive immune response to
T cell specific antigens. GCs are specialized structures within secondary lymphoid organs, in …

The germinal center (GC) reaction is a key feature of adaptive humoral immunity. GCs
represent the site where mature B cells refine their B-cell receptor (BCR) and are selected …

Abstract Models for the development and function of germinal centers (GCs) have been so
widely discussed in the original literature that they now appear in immunology textbooks …