[HTML][HTML] Effect of ginsenoside‑Rg1 on experimental Parkinson's disease: A systematic review and meta‑analysis of animal studies

YB He, YL Liu, ZD Yang, JH Lu… - Experimental and …, 2021 - spandidos-publications.com
Previous studies have reported that ginsenoside‑Rg1 (G‑Rg1) was able to mitigate the loss
of dopaminergic neurons in animal models of Parkinson's disease (PD). The present study …

A Preclinical Systematic Review of Ginsenoside‐Rg1 in Experimental Parkinson's Disease

L Song, MB Xu, XL Zhou, D Zhang… - Oxidative Medicine …, 2017 - Wiley Online Library
To date, no drug has been proven to be neuroprotective or disease‐modifying for
Parkinson's disease (PD) in clinical trials. Here, we aimed to assess preclinical evidence of …

Ginsenoside Rg1 ameliorates motor function in an animal model of Parkinson's disease

W Jiang, Z Wang, Y Jiang, M Lu, X Li - Pharmacology, 2015 - karger.com
Aims: Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of
dopaminergic neurons in the substantia nigra (SN) and diminished dopamine levels in the …

Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson's disease

T Zhou, G Zu, X Zhang, X Wang, S Li, X Gong… - …, 2016 - Elsevier
Abstract Ginsenoside Rg1 (Rg1) is a major bioactive ingredient in Panax ginseng that has
low toxicity and has been shown to have neuroprotective effects. The objectives of the …

[HTML][HTML] Neuroprotective effects of ginsenosides Rh1 and Rg2 on neuronal cells

XF Li, CNP Lui, ZH Jiang, YKL Ken - Chinese medicine, 2011 - Springer
Background The present study investigates the effects of ginsenosides Rh 1 and Rg 2
against 6-hydroxydopamine (6-OHDA), a neurotoxin on SH-SY5Y cells and PC-12 cells. The …

[HTML][HTML] New therapeutic approaches to and mechanisms of ginsenoside Rg1 against neurological diseases

Y Sun, Y Yang, S Liu, S Yang, C Chen, M Lin, Q Zeng… - Cells, 2022 - mdpi.com
Neurological diseases, including Parkinson's disease (PD), Alzheimer's disease (AD),
Huntington's disease (HD), stroke, cerebral infarction, ischemia-reperfusion injury …

Ginsenoside Rd: A promising natural neuroprotective agent

YY Chen, QP Liu, P An, M Jia, X Luan, JY Tang… - Phytomedicine, 2022 - Elsevier
Background Neurological diseases seriously affect human health, which are arousing wider
attention, and it is a great challenge to discover neuroprotective drugs with minimal side …

Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson's disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle

S Wang, Y Peng, P Fan, J Ye, W Ma, Q Wu… - Acta Pharmacologica …, 2024 - nature.com
Emerging evidence shows that psychological stress promotes the progression of
Parkinson's disease (PD) and the onset of dyskinesia in non-PD individuals, highlighting a …

Rg1 improves LPS-induced Parkinsonian symptoms in mice via inhibition of NF-κB signaling and modulation of M1/M2 polarization

J Liu, M Zhao, Z Zhang, L Cui, X Zhou… - Acta Pharmacologica …, 2020 - nature.com
Ginsenoside Rg1 is one of the most active ingredients in ginseng, which has been reported
to protect dopaminergic neurons and improve behavioral defects in MPTP model, 6-OHDA …

Ginsenoside Rg3 exerts a neuroprotective effect in rotenone-induced Parkinson's disease mice via its anti-oxidative properties

Y Han, T Wang, C Li, Z Wang, Y Zhao, J He, L Fu… - European journal of …, 2021 - Elsevier
Abstract Ginsenoside Rg3, extracted from Panax ginseng CA Meyer, has been shown to
possess neuroprotective properties. The present study aims to investigate the …