Early vs. non-early intervention in acute migraine—'Act when Mild (AwM)'. A double-blind, placebo-controlled trial of almotriptan

PJ Goadsby, G Zanchin, G Geraud… - …, 2008 - journals.sagepub.com
The study was designed to compare the response to almotriptan in migraine patients who
take medication early in the course of the attack with that when medication is taken after pain …

The 'Act when Mild'(AwM) study: a step forward in our understanding of early treatment in acute migraine

PJ Goadsby - Cephalalgia, 2008 - journals.sagepub.com
An important issue in the management of migraine is the advice given to patients as to when
to take their treatment in the course of the attack. While it seems common sense almost to …

Early intervention with almotriptan improves sustained pain‐free response in acute migraine

NT Mathew - Headache: The Journal of Head and Face Pain, 2003 - Wiley Online Library
Objective.—To determine whether treatment of migraine with almotriptan, when pain
intensity is mild, improves 1‐and 2‐hour pain‐free and sustained pain‐free rates compared …

Almotriptan improves response rates when treatment is within 1 hour of migraine onset

AJ Dowson, H Massiou, JM Lainez… - … : The Journal of Head …, 2004 - Wiley Online Library
Background.—Results from open‐label trials with almotriptan and sumatriptan have shown
higher response rates when treatment was initiated early after acute migraine onset …

Early Intervention With Almotriptan: Results of the AEGIS Trial (AXERT® Early Migraine Intervention Study)

NT Mathew, G Finlayson, TR Smith… - … : The Journal of …, 2007 - Wiley Online Library
Objective.—To evaluate prospectively the efficacy and safety of almotriptan 12.5 mg as
compared to placebo when administered within 1 hour of headache pain onset for the acute …

Within‐patient early versus delayed treatment of migraine attacks with almotriptan: The sooner the better

J Pascual, X Cabarrocas - Headache: The Journal of Head and …, 2002 - Wiley Online Library
Background.—Migraine sufferers typically have been instructed to delay triptan therapy until
headache intensity is at least moderate. Recent data suggest that earlier use of triptans may …

Consistent efficacy and tolerability of almotriptan in the acute treatment of multiple migraine attacks: results of a large, randomized, double-blind, placebo-controlled …

J Pascual, RM Falk, F Piessens, A Prusinski… - …, 2000 - journals.sagepub.com
In this double-blind study, the efficacy and tolerability of a single dose of almotriptan (6.25 or
12.5 mg) was compared with placebo in the treatment of three consecutive migraine attacks …

Almotriptan is an effective and well-tolerated treatment for migraine pain: results of a randomized, double-blind, placebo-controlled clinical trial

AJ Dowson, H Massiou, JM Lainez… - …, 2002 - journals.sagepub.com
Almotriptan is a novel and specific serotonin 5-HT1B/1D agonist for the acute treatment of
migraine. This randomized, single-dose, double-blind, multicentre, study assessed the …

Crossover, double‐blind clinical trial comparing almotriptan and ergotamine plus caffeine for acute migraine therapy

MJA Láinez, J Galvan, J Heras… - European journal of …, 2007 - Wiley Online Library
In this randomized, double‐blind, crossover clinical trial, adult patients treated two migraine
attacks: one with almotriptan 12.5 mg and the other with ergotamine 2 mg plus caffeine 200 …

Tolerability and efficacy of almotriptan in the long-term treatment of migraine

J Pascual, R Falk, R Docekal, A Prusinski… - European …, 2001 - karger.com
Background: Almotriptan is a highly specific 5-HT 1B/1D receptor agonist, which acts
selectively on blood vessels of the brain. Short-term studies have demonstrated that …