The very exciting, independent and original reports in 1973 of Snyder, Simon and Terenius
which constituted the final discovery and delineation of specific opiate receptors, after early …

Opioids, such as morphine and heroin, represent prototypic addictive drugs. Despite major
research efforts, the biological mechanisms underlying the addictive properties of these …

Although opiates have been used for medicinal and recreational purposes for many
centuries, the mechanism through which they produce their effects has only been elucidated …

As recently as ten years ago the opiate receptor was demonstrated biochemically for the first
time and it was assumed that opiate drugs produced their psychotropic actions through a …

At this time, 27 years after the initial studies on development of methadone for the
maintenance treatment of opiate addiction were begun, it has been shown that [table; see …

This review presents a chronological discussion of the discovery of opiate receptors and the
endogenous opioid peptides. After a summary of the properties and distribution of the …

Increasing our knowledge about the major addictive diseases, opiate and cocaine addiction
and alcoholism, is of great importance from a public, as well as personal health perspective …

The in vivo study of opiates and opioid peptides is complicated by the multiple receptor
affinities of the drugs presently available (Wood et al., 1981b; Wood, 1982a; Wood, 1983a) …

That the endogenous opioid system is likely to be involved in the clinical syndrome of opiate
addiction is self-evident. Yet research efforts over more than 15 years have failed to find a …

This review describes the emergence of the opioid field, in terms of both endogenous
peptides and their receptors. It discusses the basic elements of the opioid system with …