[PDF][PDF] Effects of opiates, opioid antagonists and cocaine on the endogenous opioid system: clinical and laboratory studies
MJ Kreek - NIDA Res Monogr, 1992 - researchgate.net
The very exciting, independent and original reports in 1973 of Snyder, Simon and Terenius
which constituted the final discovery and delineation of specific opiate receptors, after early …
which constituted the final discovery and delineation of specific opiate receptors, after early …
22 Endogenous Opioids and Addiction
A Herz¹, R Spanagel - Pharmacology of Opioid Peptides, 1995 - books.google.com
Opioids, such as morphine and heroin, represent prototypic addictive drugs. Despite major
research efforts, the biological mechanisms underlying the addictive properties of these …
research efforts, the biological mechanisms underlying the addictive properties of these …
The endogenous opioidergic systems
EM Unterwald, RS Zukin - Opioids, Bulimia, and Alcohol Abuse & …, 1990 - Springer
Although opiates have been used for medicinal and recreational purposes for many
centuries, the mechanism through which they produce their effects has only been elucidated …
centuries, the mechanism through which they produce their effects has only been elucidated …
The case for multiple opiate receptors
RS Zukin, SR Zukin - Trends in Neurosciences, 1984 - cell.com
As recently as ten years ago the opiate receptor was demonstrated biochemically for the first
time and it was assumed that opiate drugs produced their psychotropic actions through a …
time and it was assumed that opiate drugs produced their psychotropic actions through a …
Rationale for maintenance pharmacotherapy of opiate dependence.
MJ Kreek - Research Publications-Association for Research in …, 1992 - europepmc.org
At this time, 27 years after the initial studies on development of methadone for the
maintenance treatment of opiate addiction were begun, it has been shown that [table; see …
maintenance treatment of opiate addiction were begun, it has been shown that [table; see …
Opiate receptors and endorphins: possible relevance to narcotic addiction
EJ Simon - Advances in Alcohol & Substance Abuse, 1982 - Taylor & Francis
This review presents a chronological discussion of the discovery of opiate receptors and the
endogenous opioid peptides. After a summary of the properties and distribution of the …
endogenous opioid peptides. After a summary of the properties and distribution of the …
Opiates, opioids and addiction.
MJ Kreek - Molecular psychiatry, 1996 - europepmc.org
Increasing our knowledge about the major addictive diseases, opiate and cocaine addiction
and alcoholism, is of great importance from a public, as well as personal health perspective …
and alcoholism, is of great importance from a public, as well as personal health perspective …
Central actions of opiates and opioid peptides: In vivo evidence for opioid receptor multiplicity
PL Wood, S Iyengar - The opiate receptors, 1988 - Springer
The in vivo study of opiates and opioid peptides is complicated by the multiple receptor
affinities of the drugs presently available (Wood et al., 1981b; Wood, 1982a; Wood, 1983a) …
affinities of the drugs presently available (Wood et al., 1981b; Wood, 1982a; Wood, 1983a) …
Opioid addiction
CP O'Brien - Opioids II, 1993 - Springer
That the endogenous opioid system is likely to be involved in the clinical syndrome of opiate
addiction is self-evident. Yet research efforts over more than 15 years have failed to find a …
addiction is self-evident. Yet research efforts over more than 15 years have failed to find a …
Molecular and neuroanatomical properties of the endogenous opioid system: implications for treatment of opiate addiction
H Akil, F Meng, DP Devine, SJ Watson - Seminars in neuroscience, 1997 - Elsevier
This review describes the emergence of the opioid field, in terms of both endogenous
peptides and their receptors. It discusses the basic elements of the opioid system with …
peptides and their receptors. It discusses the basic elements of the opioid system with …