Mechanisms that regulate host defense after noninfectious tissue injury are incompletely
understood. Our laboratory is interested in the role of the extracellular matrix …

Mechanisms that regulate inflammation and repair after acute lung injury are incompletely
understood. The extracellular matrix glycosaminoglycan hyaluronan is produced after tissue …

A hallmark of tissue injury and repair is the turnover of extracellular matrix components. This
review focuses on the role of the glycosaminoglycan hyaluronan in tissue injury and repair …

Hyaluronan is a high-molecular mass component of pulmonary extracelluar matrix, and lung
injury can generate a low-molecular mass hyaluronan (HA) fragment that functions as …

The role of Toll-like receptors (TLRs) in pathogen recognition has been expeditiously
advanced in recent years. However, investigations into the function of TLRs in non-infectious …

Hyaluronan is a hygroscopic glycosaminoglycan that contributes to both extracellular and
pericellular matrices. While the production of hyaluronan is essential for mammalian …

Acute lung injury results in early inflammation and respiratory distress, and later fibrosis. The
glycosaminoglycan hyaluronan (HA) and the Receptor for Hyaluronan-Mediated Motility …

Lung fibrosis and tissue remodeling are features of chronic diseases such as severe
asthma, idiopathic pulmonary fibrosis, and systemic sclerosis. However, fibrosis-targeted …

Airway epithelium is emerging as a regulator of local inflammation and immune responses.
However, the cellular and molecular mechanisms responsible for the immune modulation by …

Ozone exposure is associated with exacerbation of reactive airways disease. We have
previously reported that the damage-associated molecular pattern, hyaluronan, is required …