Macrophage-biomimetic liposomes delivery of carbon dots nanozymes ameliorate ulcerative colitis by modulating inflammation pathways and remodeling the redox …

Y Ma, J Zhao, Z Deng, B Gao, C Xu, X Yan… - Chemical Engineering …, 2023 - Elsevier
As a recurrent chronic inflammatory intestinal disease, ulcerative colitis (UC) has seriously
affected the life quality of patients. Numerous studies have demonstrated excessive reactive …

Biomimetic MOF nanoparticles delivery of C-dot nanozyme and CRISPR/Cas9 system for site-specific treatment of ulcerative colitis

Y Ma, W Gao, Y Zhang, M Yang, X Yan… - … Applied Materials & …, 2022 - ACS Publications
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) of unknown etiology
affecting the colon and rectum. Previous studies have found that reactive oxygen species …

Antioxidant enzymes sequestered within lipid–polymer hybrid nanoparticles for the local treatment of inflammatory bowel disease

Z Le, Z He, H Liu, L Liu, Z Liu… - ACS Applied Materials & …, 2021 - ACS Publications
The local treatment of inflammatory bowel disease (IBD) by enzyme therapeutics is
challenging owing to hostile environments in the gastrointestinal tract, leading to the …

Oral nanozyme-engineered probiotics for the treatment of ulcerative colitis

H Zhao, Y Du, L Liu, Y Du, K Cui, P Yu, L Li… - Journal of Materials …, 2022 - pubs.rsc.org
Probiotic-based therapy for ulcerative colitis (UC) is a novel and promising approach that
has gained much popularity in recent years. However, probiotics may be easily captured …

[HTML][HTML] Amelioration of ulcerative colitis via inflammatory regulation by macrophage-biomimetic nanomedicine

T Sun, CHT Kwong, C Gao, J Wei, L Yue, J Zhang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Ulcerative colitis (UC) is featured with relapsing inflammation in the colon, where
macrophages are recruited and polarized locally into M1 type to drive further inflammation …

Versatile carbon dots with superoxide dismutase-like nanozyme activity and red fluorescence for inflammatory bowel disease therapeutics

Y Ma, J Zhao, L Cheng, C Li, X Yan, Z Deng, Y Zhang… - Carbon, 2023 - Elsevier
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease
(CD), is a chronic and recurrent disease that seriously affects the life quality of patients …

[HTML][HTML] “Dual sensitive supramolecular curcumin nanoparticles” in “advanced yeast particles” mediate macrophage reprogramming, ROS scavenging and …

X Han, R Luo, S Qi, Y Wang, L Dai, W Nie, M Lin… - Journal of …, 2023 - Springer
Ulcerative colitis (UC) faces some barriers in oral therapy, such as how to safely deliver
drugs to the colon and accumulate in the colon lesions. Hence, we report an advanced yeast …

ROS-responsive nanoparticles targeting inflamed colon for synergistic therapy of inflammatory bowel disease via barrier repair and anti-inflammation

D Wang, Q Jiang, R Shen, L Peng, W Zhou, T Meng… - Nano Research, 2024 - Springer
The destruction of the intestinal barrier is likely to cause an increase in intestinal
permeability and cause pathological damage. Numerous studies have demonstrated that …

Construction of pH‐Dependent Nanozymes with Oxygen Vacancies as the High‐Efficient Reactive Oxygen Species Scavenger for Oral‐Administrated Anti …

N Zhao, FE Yang, CY Zhao, SW Lv… - Advanced …, 2021 - Wiley Online Library
It is of great significance to eliminate excessive reactive oxygen species (ROS) for treating
inflammatory bowel disease (IBD). Herein, for the first time, a novel nanozyme NiCo2O4 …

[HTML][HTML] Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis therapy

C Liu, X Yan, Y Zhang, M Yang, Y Ma, Y Zhang… - Journal of …, 2022 - Springer
Background Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by
diffuse inflammation of the colonic mucosa and a relapsing and remitting course. The current …