The 18S rRNA m6A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation
RNA modifications represent a novel layer of regulation of gene expression. Functional
experiments revealed that N6‐methyladenosine (m6A) on messenger RNA (mRNA) plays …
experiments revealed that N6‐methyladenosine (m6A) on messenger RNA (mRNA) plays …
The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs
VV Ignatova, P Stolz, S Kaiser… - Genes & …, 2020 - genesdev.cshlp.org
Covalent chemical modifications of cellular RNAs directly impact all biological processes.
However, our mechanistic understanding of the enzymes catalyzing these modifications …
However, our mechanistic understanding of the enzymes catalyzing these modifications …
[HTML][HTML] Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
X Liu, H Wang, X Zhao, Q Luo, Q Wang, K Tan… - Nature …, 2021 - nature.com
Abstract RNA N 6-methyladenosine (m6A), the most abundant internal modification of
mRNAs, plays key roles in human development and health. Post-translational methylation of …
mRNAs, plays key roles in human development and health. Post-translational methylation of …
METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity
METTL3 and METTL14 are two components that form the core heterodimer of the main RNA
m6A methyltransferase complex (MTC) that installs m6A. Surprisingly, depletion of METTL3 …
m6A methyltransferase complex (MTC) that installs m6A. Surprisingly, depletion of METTL3 …
Mettl14 is required for mouse post-implantation development by facilitating epiblast maturation
TG Meng, X Lu, L Guo, GM Hou, XS Ma, QN Li… - bioRxiv, 2018 - biorxiv.org
ABSTRACT N6-methyladenosine (m6A) is the most prevalent and reversible internal
modification of mammalian messenger and noncoding RNAs mediated by specific m6A …
modification of mammalian messenger and noncoding RNAs mediated by specific m6A …
[HTML][HTML] Methylation of structured RNA by the m6A writer METTL16 is essential for mouse embryonic development
Internal modification of RNAs with N 6-methyladenosine (m 6 A) is a highly conserved
means of gene expression control. While the METTL3/METTL14 heterodimer adds this mark …
means of gene expression control. While the METTL3/METTL14 heterodimer adds this mark …
[HTML][HTML] m6A RNA modification controls cell fate transition in mammalian embryonic stem cells
Summary N6-methyl-adenosine (m 6 A) is the most abundant modification on messenger
RNAs and is linked to human diseases, but its functions in mammalian development are …
RNAs and is linked to human diseases, but its functions in mammalian development are …
[HTML][HTML] m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency
Summary N 6-methyladenosine (m 6 A) has been recently identified as a conserved
epitranscriptomic modification of eukaryotic mRNAs, but its features, regulatory mechanisms …
epitranscriptomic modification of eukaryotic mRNAs, but its features, regulatory mechanisms …
[HTML][HTML] METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells
M Mu, X Li, L Dong, J Wang, Q Cai, Y Hu, D Wang… - Cell reports, 2023 - cell.com
Summary METTL14 (methyltransferase-like 14) is an RNA-binding protein that partners with
METTL3 to mediate N 6-methyladenosine (m 6 A) methylation. Recent studies identified a …
METTL3 to mediate N 6-methyladenosine (m 6 A) methylation. Recent studies identified a …
m6A deposition is regulated by PRMT1‐mediated arginine methylation of METTL14 in its disordered C‐terminal region
Abstract The N6‐methyladenosine (m6A) RNA modification serves crucial functions in RNA
metabolism; however, the molecular mechanisms underlying the regulation of m6A are not …
metabolism; however, the molecular mechanisms underlying the regulation of m6A are not …