Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease
VKM Halagappa, Z Guo, M Pearson, Y Matsuoka… - Neurobiology of …, 2007 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
decline in cognitive function associated with the neuropathological hallmarks amyloid β …
decline in cognitive function associated with the neuropathological hallmarks amyloid β …
Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models
NV Patel, MN Gordon, KE Connor, RA Good… - Neurobiology of …, 2005 - Elsevier
Dietary influences on Alzheimer disease (AD) are gaining recognition. Because many aging
processes are attenuated in laboratory mammals by caloric restriction (CR), we examined …
processes are attenuated in laboratory mammals by caloric restriction (CR), we examined …
Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice
PR Mouton, ME Chachich, C Quigley, E Spangler… - Neuroscience …, 2009 - Elsevier
Caloric restriction (CR) mitigates neurological damage arising from aging and a variety of
other sources, including neuropathology in young adult mice that express single and double …
other sources, including neuropathology in young adult mice that express single and double …
[HTML][HTML] High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology
EM Knight, IVA Martins, S Gümüsgöz, SM Allan… - Neurobiology of …, 2014 - Elsevier
Obesity and consumption of a high-fat diet are known to increase the risk of Alzheimer's
disease (AD). Diets high in fat also increase disease neuropathology and/or cognitive …
disease (AD). Diets high in fat also increase disease neuropathology and/or cognitive …
Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic …
M Maesako, K Uemura, M Kubota, A Kuzuya… - Journal of Biological …, 2012 - ASBMB
Accumulating evidence suggests that some dietary patterns, specifically high fat diet (HFD),
increase the risk of developing sporadic Alzheimer disease (AD). Thus, interventions …
increase the risk of developing sporadic Alzheimer disease (AD). Thus, interventions …
Protein restriction cycles reduce IGF‐1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model
E Parrella, T Maxim, F Maialetti, L Zhang, J Wan… - Aging cell, 2013 - Wiley Online Library
In laboratory animals, calorie restriction (CR) protects against aging, oxidative stress, and
neurodegenerative pathologies. Reduced levels of growth hormone and IGF‐1, which …
neurodegenerative pathologies. Reduced levels of growth hormone and IGF‐1, which …
[PDF][PDF] Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models
P Rangan, F Lobo, E Parrella, N Rochette, M Morselli… - Cell reports, 2022 - cell.com
The effects of fasting-mimicking diet (FMD) cycles in reducing many aging and disease risk
factors indicate it could affect Alzheimer's disease (AD). Here, we show that FMD cycles …
factors indicate it could affect Alzheimer's disease (AD). Here, we show that FMD cycles …
[HTML][HTML] Contributions of a high-fat diet to Alzheimer's disease-related decline: a longitudinal behavioural and structural neuroimaging study in mouse models
CPE Rollins, D Gallino, V Kong, G Ayranci… - NeuroImage: Clinical, 2019 - Elsevier
Obesity is recognized as a significant risk factor for Alzheimer's disease (AD). Studies have
supported that obesity accelerates AD-related pathophysiology and memory impairment in …
supported that obesity accelerates AD-related pathophysiology and memory impairment in …
Mitochondrial abnormalities and synaptic loss underlie memory deficits seen in mouse models of obesity and Alzheimer's disease
Obesity is associated with impaired memory in humans, and obesity induced by high-fat
diets leads to cognitive deficits in rodents and in mouse models of Alzheimer's disease (AD) …
diets leads to cognitive deficits in rodents and in mouse models of Alzheimer's disease (AD) …
Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice
MJ Schafer, MJ Alldred, SH Lee, ME Calhoun… - Neurobiology of …, 2015 - Elsevier
Research indicates that female risk of developing Alzheimer's disease (AD) is greater than
that of males. Moderate reduction of calorie intake, known as calorie restriction (CR) …
that of males. Moderate reduction of calorie intake, known as calorie restriction (CR) …