Nanoparticle-based delivery systems as emerging therapy in retinoblastoma: recent advances, challenges and prospects

AL Onugwu, OL Ugorji, CA Ufondu, SA Ihim… - Nanoscale …, 2023 - pubs.rsc.org
Retinoblastoma is the most common intraocular malignancy in children. The treatment of this
rare disease is still challenging in developing countries due to delayed diagnosis. The …

Nanotechnology for pediatric retinoblastoma therapy

E Russo, A Spallarossa, B Tasso, C Villa, C Brullo - Pharmaceuticals, 2022 - mdpi.com
Retinoblastoma is a rare, sometimes hereditary, pediatric cancer. In high-income countries
this disease has a survival rate approaching 100%, while in low-and middle-income …

Management of retinoblastoma: opportunities and challenges

D Bhavsar, K Subramanian, S Sethuraman… - Drug …, 2016 - Taylor & Francis
Nano-delivery systems have significantly evolved over the last decade for the treatment of
cancer by enabling site-specific delivery and improved bioavailability. The widely …

Nanoparticle-mediated gene therapy as a novel strategy for the treatment of retinoblastoma

M Mandal, I Banerjee, M Mandal - Colloids and Surfaces B: Biointerfaces, 2022 - Elsevier
Over the last two decades, nanoparticulate delivery systems have revolutionized cancer
treatment by achieving target-specific delivery, enhanced bioavailability, and improved …

[HTML][HTML] Multi-functionalized nanomaterials and nanoparticles for diagnosis and treatment of retinoblastoma

R Arshad, M Barani, A Rahdar, S Sargazi… - Biosensors, 2021 - mdpi.com
Retinoblastoma is a rare type of cancer, and its treatment, as well as diagnosis, is
challenging, owing to mutations in the tumor-suppressor genes and lack of targeted …

Advances in biomaterials for the treatment of retinoblastoma

W Farhat, V Yeung, A Ross, F Kahale, N Boychev… - Biomaterials …, 2022 - pubs.rsc.org
Retinoblastoma is the most common primary intraocular malignancy in children. Although
traditional chemotherapy has shown some success in retinoblastoma management, there …

Advancements in Nanosystems for Ocular Drug Delivery: A Focus on Pediatric Retinoblastoma

KY Wu, XC Wang, M Anderson, SD Tran - Molecules, 2024 - mdpi.com
The eye's complex anatomical structures present formidable barriers to effective drug
delivery across a range of ocular diseases, from anterior to posterior segment pathologies …

Nanoparticulate drug delivery to the retina

Q Li, J Weng, SN Wong, WY Thomas Lee… - Molecular …, 2020 - ACS Publications
Retinal diseases, such as age-related macular degeneration and diabetic retinopathy, are
the leading causes of blindness worldwide. The mainstay of treatment for these blinding …

Retinoblastoma: An update on genetic origin, classification, conventional to next-generation treatment strategies

A Pareek, D Kumar, A Pareek, MM Gupta, P Jeandet… - Heliyon, 2024 - cell.com
The most prevalent paediatric vision-threatening medical condition, retinoblastoma (RB),
has been a global concern for a long time. Several conventional therapies, such as systemic …

Frontiers in the treatment of glioblastoma: Past, present and emerging

TI Janjua, P Rewatkar, A Ahmed-Cox, I Saeed… - Advanced drug delivery …, 2021 - Elsevier
Glioblastoma (GBM) is one of the most aggressive cancers of the brain. Despite extensive
research over the last several decades, the survival rates for GBM have not improved and …