Uric acid and cardiovascular disease: an update from molecular mechanism to clinical perspective

W Yu, JD Cheng - Frontiers in pharmacology, 2020 - frontiersin.org
Uric acid (UA) is the end product of purine nucleotide metabolism in the human body.
Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and …

Uric acid and cardiometabolic diseases

SJ Lee, BK Oh, KC Sung - Clinical hypertension, 2020 - Springer
Hyperuricemia, which has been considered as a cause of gout and nephrolithiasis has
recently been suggested to be associated with hypertension, coronary heart disease, heart …

Hyperuricemia and cardiovascular disease

S Zhang, Y Wang, J Cheng, N Huangfu… - Current …, 2019 - ingentaconnect.com
Purine metabolism in the circulatory system yields uric acid as its final oxidation product,
which is believed to be linked to the development of gout and kidney stones. Hyperuricemia …

Chronic hyperuricemia, uric acid deposit and cardiovascular risk

D Grassi, L Ferri, G Desideri, P Di Giosia… - Current …, 2013 - ingentaconnect.com
Hyperuricemia is commonly associated with traditional risk factors such as dysglicemia,
dyslipidemia, central obesity and abnormal blood pressure, ie the metabolic syndrome …

Advances in pharmacotherapies for hyperuricemia

F Piani, D Agnoletti, C Borghi - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Hyperuricemia is an overlooked cardiovascular and renal risk factor.
Epidemiological and genetic studies have shown an independent role of uric acid in the risk …

Harnessing hyperuricemia to atherosclerosis and understanding its mechanistic dependence

M Jayachandran, S Qu - Medicinal research reviews, 2021 - Wiley Online Library
Atherosclerosis is regarded as the disease of the arterial vasculature. The main
characteristics of atherosclerosis are the abnormal accumulation of lipids, increased …

[HTML][HTML] Uric acid and cardiovascular disease: a clinical review

Y Saito, A Tanaka, K Node, Y Kobayashi - Journal of cardiology, 2021 - Elsevier
Uric acid, the end-product of purine metabolism in humans, is not only a cause of gout, but
also may play roles in developing cardiovascular diseases such as hypertension, atrial …

[HTML][HTML] Uric acid in inflammation and the pathogenesis of atherosclerosis

Y Kimura, D Tsukui, H Kono - International journal of molecular sciences, 2021 - mdpi.com
Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors
for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological …

Allopurinol as a cardiovascular drug

A Kelkar, A Kuo, WH Frishman - Cardiology in review, 2011 - journals.lww.com
Cardiovascular disease (CVD) remains the leading cause of death in the United States.
There is evidence that shows a direct relationship between an elevated uric acid level and …

Hyperuricemia and the risk of heart failure: pathophysiology and therapeutic implications

K Si, C Wei, L Xu, Y Zhou, W Lv, B Dong… - Frontiers in …, 2021 - frontiersin.org
The association between hyperuricemia and cardiovascular disease (CVD) has been
reported and studied in the past two decades. Xanthine oxidase (XO) induced uric acid (UA) …