BACKGROUND-Increasing studies investigating the association between steroid 5-alpha
reductase type II gene polymorphism at codon 89 (SRD5A2 V89L) and susceptibility to …

BACKGROUND Increasing studies investigating the association between steroid 5‐alpha
reductase type II gene polymorphism at codon 89 (SRD5A2 V89L) and susceptibility to …

The pathogenetic mechanism of prostate cancer (PCa) has not been understood completely,
and gene polymorphisms have been demonstrated to play a critical role in the course. It has …

Numerous investigations have examined the associations between steroid 5-alpha-
reductase type 2 (SRD5A2) V89L and A49T polymorphisms and prostate cancer risk; …

Abstract Steroid 5-α-reductase type 2 (SRD5a2) is a critical enzyme in androgen
metabolism. Two polymorphisms in the SRD5a2 gene, V89L (rs523349) and A49T …

Several polymorphisms in the 5α-reductase type 2 (SRD5A2) gene have been implicated as
risk factors for prostate cancer. We performed a meta-analysis of 9 studies (12 comparisons) …

The pathogenetic mechanism of prostate cancer (PCa) has not been understood completely,
and gene polymorphisms have been demonstrated to play a critical role in the course. It has …

Androgens are actively involved in the development of the prostate gland and appear to be
essential for prostate carcinogenesis. The product of the SRD5A2 gene, membrane‑bound …

PURPOSE: The SRD5A2 gene codes the steroid 5-reductase type II, a critical mediator of
androgen action, and the V89L and A49T polymorphisms of this gene may be associated …

The steroid 5-alpha reductase type II gene (SRD5A2) encodes the enzyme which converts
testosterone (T) to the more active androgen dihydrotestosterone. A non-synonymous single …