Flavan-3-ols are involved in multiple metabolic pathways that induce inhibition of cell
proliferation. We studied the structure-activity relationship of gallic acid (GA) and four flavan …

Most anticancer drugs have their origin in traditional medicinal plants. We describe here a
flavone, 5, 3′-dihydroxy-3, 6, 7, 8, 4′-pentamethoxyflavone (PMF), from the leaves of the …

Breast cancer is the leading cause of cancer death in women worldwide. Due to the side
effects of current chemo‐reagents on healthy tissues, it is essential to search for alternative …

In parallel to the continuous rise of new cancer cases all over the world, the interest of
scientific community in natural anticancer agents has steadily been increased. In the past …

As part of our continuing investigation of polymethoxyflavone (PMF) derivatives as potential
anticancer substances, a series of PMF derivatives was synthesized. The synthesized …

Acute myeloid leukemia (AML) is characterized by the dysregulation of hematopoietic cell
proliferation, resulting in the accumulation of immature myeloid cells in bone marrow. 5 …

The combination of compounds with complementary bioactivities into hybrid molecules is an
emerging concept in drug discovery. In this study, we aimed to synthesize new hybrid …

Background Among all breast cancers, Triple negative breast cancer (TNBC) is the most
aggressive subtype with an increased metastatic and relapse rate. Presently, the only …

Malignant melanoma is one of the most aggressive skin cancer and highly resistant to most
conventional treatment. In the present study, we aimed to investigate the anticancer effects …

Cancer has remained to be one of the major challenges in medicine and regarded as the
second leading cause of death worldwide. Different types of cancer may resist anti-cancer …