Using a rat C6 brain tumor model, we studied the antitumor effects of Herpes simplex virus
type 1 thymidine kinase (HSV-tk) gene transfer followed by ganciclovir treatment. C6 glioma …

Magnetic resonance imaging and in vivo localized H magnetic resonance spectroscopy
were used to evaluate a gene therapy approach for treating experimental brain tumors. This …

The herpes simplex virus thymidine kinase gene was transferred into C6 glioma cells by
infection with a recombinant adenovirus. In vitro, a 10 microM ganciclovir concentration was …

Contradictory experimental results and human trials have questioned the clinical relevance
of the HSVtk/ganciclovir system. To bypass the problem of transfection efficiency, we used a …

The transfer of the gene coding for the thymidine kinase of the herpes simplex virus (HSV-
tk), followed by ganciclovir (GCV) administration, has been described for the treatment of …

We have used high resolution magnetic resonance imaging to monitor malignant rat BT4C
gliomas in vivo following herpes simplex virus thymidine kinase gene and ganciclovir (GCV) …

Transfer of the herpes simplex virus thymidine kinase (HSVtk) gene, followed by
administration of ganciclovir (GCV), generates the “bystander effect,” in which HSVtk …

Survival of rats harboring cerebral 9L gliosarcomas can be significantly extended by an
intratumoral inoculation with a herpes simplex virus vector, designated as hrR3. This vector …

Transfer of a herpes simplex virus-derived thymidine kinase (HSV-tk) gene into brain tumor
cells and subsequent ganciclovir (GCV) treatment has been shown by others to be an …

Transduction of experimental gliomas with the herpes simplex virus thymidine kinase gene
(HSV-tk) using a replication-defective adenoviral vector (ADV/RSV-tk) confers sensitivity to …