The role of mitochondria is emerging in regulation of innate immunity, inflammation and cell
death beyond its primary role in energy metabolism. Mitochondria act as molecular platform …

Mitochondria are known to be semi-autonomous organelles that are responsible for energy
production and cellular respiration. Mitochondria break down glucose to release energy in …

NLRX1 is the only member of the Nod-like receptor (NLR) family that is targeted to the
mitochondria, and its overexpression induces the generation of reactive oxygen species …

NLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors
associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its …

Innate immunity is a crucial defense system against viral and bacterial pathogens, providing
a rapid response to mitigate the effects of microbial attack. While more readily associated …

NOD‐like receptors (NLRs) are a family of intracellular sensors of microbial‐or danger‐
associated molecular patterns. Here, we report the identification of NLRX1, which is a new …

To subvert host immunity, influenza A virus (IAV) induces early apoptosis in innate immune
cells by disrupting mitochondria membrane potential via its polymerase basic protein 1 …

NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique
pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting …

Nucleotide binding and oligomerization domain (NOD)-like receptor (NLR) initially appeared
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …

The RIG-like helicase (RLH) family of intracellular receptors detect viral nucleic acid and
signal through the mitochondrial antiviral signalling adaptor MAVS (also known as Cardif …