It has been recently shown that the Alzheimer's disease (AD) pathogenic peptide amyloid β1–
42 (Aβ1–42) binds to the α7 nicotinic acetylcholine receptor (α7nAChR) with high affinity …

Alzheimer's disease pathology is characterized by the presence of neuritic plaques and the
loss of cholinergic neurons in the brain. The underlying mechanisms leading to these events …

Accumulation of the amyloid protein (Aβ) in the brain is an important step in the
pathogenesis of Alzheimer's disease. However, the mechanism by which Aβ exerts its …

The accumulation of amyloid-beta peptide (Aβ) and the failure of cholinergic transmission
are key players in Alzheimer's disease (AD). However, in the healthy brain, Aβ contributes to …

Alzheimer's disease (AD) is a chronic neurodegenerative, and abnormal aggregation of the
neurotoxic β amyloid (Aβ) peptide is an early event in AD. The present study aimed to …

Although there is still no known effective preventative treatment or cure for Alzheimer's
disease (AD), the development of new drugs that target pathological features that appear …

Alzheimer's disease (AD) is one of the major disabling and lethal diseases for aged
individuals worldwide. To date, there are more than 10 hypotheses proposed for AD …

Deterioration of the cortical cholinergic system is a leading neurochemical feature of
Alzheimer's Disease (AD). This review summarizes evidence that the homomeric α7 …

Alzheimer's Disease (AD) is the most common of the senile dementias, the prevalence of
which is increasing rapidly, with a projected 14 million affected worldwide by 2025. The …

The nicotinic receptors (nAChRs), which play a critical role in cognitive function, are
impaired early in the course of Alzheimer's disease (AD). We have previously demonstrated …