Abstract Study Objectives: Prolonged wakefulness leads to a progressive increase in sleep
pressure, reflected in a global increase in slow wave activity (SWA, 0.5-4.5 Hz) in the sleep …

Recent work has demonstrated that behavioral manipulations targeting specific cortical
areas during prolonged wakefulness lead to a region-specific homeostatic increase in theta …

Objective Evidence from previous studies suggests that greater sleep pressure, in the form
of EEG-based slow waves, accumulates in specific brain regions that are more active during …

The electrical activity of the brain does not only reflect the current level of arousal, ongoing
behavior, or involvement in a specific task but is also influenced by what kind of activity, and …

We used the waking electroencephalogram to study the homeostatic sleep regulatory
process in human short sleepers and long sleepers. After sleeping according to their …

Sleep is regulated by a homeostatic process which in the two-process model of human
sleep regulation is represented by electroencephalogram slow-wave activity (SWA). Many …

During non-rapid eye movement (NREM) sleep, cortical neurons alternate between ON
periods of firing and OFF periods of silence. This bi-stability, which is largely synchronous …

Subjective sleepiness is part of the system controlling the decision to go to sleep in humans.
Extended periods of waking lead to increased sleepiness, as well as to changes in cortical …

Sleep is homeostatically regulated in all animal species that have been carefully studied so
far. The best characterized marker of sleep homeostasis is slow wave activity (SWA), the …

Slow wave sleep (SWS) is associated with spontaneous brain oscillations that are thought to
participate in sleep homeostasis and to support the processing of information related to the …