Lymphocytes depend on endothelial adhesion molecules such as ICAM-1 and VCAM-1,
upregulated with inflammation, to facilitate transmigration across junctional barriers. New …

Adhesion molecules of the immunoglobulin superfamily are crucial effectors of leukocyte
trafficking into the central nervous system. Using a lipid raft-based proteomic approach, we …

Activated leukocyte cell adhesion molecule (ALCAM) has been proposed to mediate
leukocyte migration across the blood–brain barrier (BBB) in multiple sclerosis or …

Lymphocyte recruitment to the central nervous system (CNS) is a critical step in the
pathogenesis of diseases such as multiple sclerosis (MS), meningitis and posterior uveitis …

The presence of B lymphocyte–associated oligoclonal immunoglobulins in the
cerebrospinal fluid is a classic hallmark of multiple sclerosis (MS). The clinical efficacy of anti …

The transvascular migration of lymphocytes and other leukocytes from blood to peripheral
tissues is preceded by adherence of these cells to endothelial cells (EC) lining the …

Endothelial cells of the blood-brain barrier (BBB) have the ability to regulate and restrict the
passage of cells and molecules from the periphery to the CNS. We have used an in vitro …

Activated leukocyte cell adhesion molecule (ALCAM) is a cell adhesion molecule found on
blood–brain barrier endothelial cells (BBB-ECs) that was previously shown to be involved in …

Leukocyte transmigration into the central nervous system promotes multiple sclerosis
pathogenesis, yet ambiguity remains regarding the mechanisms controlling the migration of …

Lymphocyte extravasation into the brain is mediated largely by the Ig superfamily molecule
ICAM-1. Several lines of evidence indicate that at the tight vascular barriers of the central …