Summary The Aryl hydrocarbon receptor (Ahr) regulates the differentiation and function of
CD4+ T cells; however, its cell-intrinsic role in CD8+ T cells remains elusive. Herein we …

The intestinal immune system is challenged daily with the task of recognizing and
eliminating pathogens while simultaneously tolerating dietary and commensal antigens. All …

Innate lymphoid cells (ILCs) expressing the nuclear receptor RORγt are essential for gut
immunity presumably through production of interleukin-22 (IL-22). The molecular …

Multiple sclerosis (MS) is a T cell-driven autoimmune disease that attacks the myelin of the
central nervous system (CNS) and currently has no cure. MS etiology is linked to both the …

The aryl hydrocarbon receptor (Ahr) is a ligand-dependent transcription factor and facilitates
immune cell environmental sensing through its activation by cellular, dietary, and microbial …

With striking similarity to their adaptive T helper cell counterparts, innate lymphoid cells
(ILCs) represent an emerging family of cell types that express signature transcription factors …

An immunoregulatory role of aryl hydrocarbon receptor (AhR) has been shown in
conventional αβ and γδ T cells, but its function in skin γδ T cells (dendritic epidermal T cells …

The aryl hydrocarbon receptor (AHR) is an important regulator of the development and
function of both innate and adaptive immune cells through roles associated with AHR's …

Diet and microbiome derived indole derivatives are known to activate the ligand induced
transcription factor, the Aryl hydrocarbon Receptor (AhR). While the current understanding of …

Activation of the aryl hydrocarbon receptor (AhR) by immunosuppressive ligands promotes
the development of regulatory T (Treg) cells. Although AhR‐induced Foxp3+ Treg cells have …