In the SEAQUAMAT trial, parenteral artesunate was shown to be associated with a
considerably lower mortality than quinine, and is now the recommended treatment for …

Severe malaria is a global problem, claiming at least 1 million lives annually. Few
adequately powered clinical studies have been directed at improving the management of …

Artemisinin derivatives, such as artesunate, have a short half-life and very rapid anti-malarial
activity. Theoretically, using such agents in conjunction with well-established anti-malarial …

Documentation on the efficacy of artesunate in Africa is limited, and no experience of
artesunate use in Sudan is documented. Severe malaria in rural areas of Sudan, where …

Severe malaria remains a major cause of mortality and morbidity for children living in many
tropical regions. With the emergence of strains of Plasmodium falciparum resistant to both …

Artemether is an oil-soluble methyl ether of artemesinin (qinghaosu). It has been studied
extensively in China, where it has been shown to be rapidly effective in severe falciparum …

Sixty-six children presenting to Singa hospital, Sudan with different manifestations of severe
Plasmodium falciparum malaria were randomly divided into two well-matched groups (33 in …

The case fatality of WHO-defined'severe falciparum malaria'remains unacceptably high, at
10-20%. However, a gradual decline in case fatality in adults and children treated in …

Plasmodium falciparum has developed resistance to almost all routinely used antimalarial
drugs. Sulfadoxine-pyrimethamine (SP) has replaced chloroquine as first-line treatment of …

Background Resistance to cheap effective antimalarial drugs, especially to pyrimethamine-
sulphadoxine (Fansidar), is likely to have a striking impact on childhood mortality in sub …