Objective Intestinal gluconeogenesis, via the initiation of a gut-brain nervous circuit,
accounts for the metabolic benefits linked to dietary proteins or fermentable fibre in rodents …

Pre-operative exercise therapy improves outcomes for many patients who undergo surgery.
Despite the well-known effects on tolerance to systemic perturbation, the mechanisms by …

In this issue of Molecular Metabolism, Dushay et al. report new results demonstrating
fructose ingestion in humans acutely and robustly raises circulating levels of fibroblast …

Protein restriction (PR) is important for the benefits of dietary restriction on longevity and
stress resistance, but relevant nutrient sensors and downstream effectors in mammals …

Background Despite a consistent link between obesity and increased circulating levels of
fibroblast growth factor-21 (FGF21), the effect of weight-loss interventions on FGF21 is not …

Dietary or calorie restriction (DR, CR), defined as reduced food intake without malnutrition,
imparts many benefits in model organisms. Extended longevity is the most popularized …

Caloric restriction (CR) increases healthy life span in a range of organisms. The underlying
mechanisms are not understood but appear to include changes in gene expression, protein …

Obesity in mice and humans is associated with elevated levels of at least two hormones
responsive to cellular stress, namely GDF15 and FGF21. Over-expression of each of these is …

Vertical sleeve gastrectomy (VSG) is the best current therapy for remission of obesity and its
comorbidities. It is understood to alter the enterohepatic circulation of bile acids in vivo …

Background: Cellular metabolic dysfunction is associated with occurrence of multiple‐organ
failure after critical illness. Glutamine (GLN) attenuates cellular metabolic dysfunction in …