Dinitroanilines are small, synthetic molecules that selectively disrupt microtubules in plants
and protozoa, and lack activity against vertebrate or fungal microtubules. This selective …

Plant and protozoan microtubules are selectively sensitive to dinitroanilines, which do not
disrupt vertebrate or fungal microtubules. Tetrahymena thermophila is an abundant source …

Protozoan parasites are remarkably sensitive to dinitroanilines such as oryzalin, which
disrupt plant but not animal microtubules. To explore the basis of dinitroaniline action, we …

The dinitroanilines are small molecules that selectively bind to plant and protozoan tubulin
dimers and disrupt microtubules in these organisms. Despite the high degree of sequence …

The human parasite Toxoplasma gondii is sensitive to dinitroaniline compounds which
selectively disrupt microtubules in diverse protozoa but which have no detectable effect on …

Protozoan microtubules are sensitive to disruption by dinitroanilines, compounds that kill
intracellular Toxoplasma gondii parasites without affecting microtubules in vertebrate host …

Despite years of use as commercial herbicides, it is still unclear how dinitroanilines interact
with tubulin, how they cause microtubule disassembly, and why they are selectively active …

Since tubulin is a known anticancer and anthelmintic drug target, the investigation of
protozoal tubulin could lead to the development of new antiparasitic drugs. This review …

Characteristics of the interaction of dinitroaniline compounds with tubulin molecules have an
extremely high selectivity: these substances efficiently bind to the tubulins of both plant and …

Many naturally occurring compounds and their synthetic analogs bind to soluble tubulin or to
tubulin in microtubules. These compounds are often important drugs or drug candidates …