Sodium salicylate and acetylsalicylic acid are drugs used as anti-inflammatory agents.
Salicylate prevents nuclear factor-κB activation and can cause apoptosis. However …

Doxorubicin (DOX) is a potent anti-neoplastic antibiotic used to treat a variety of
malignancies; however, its use is limited by dose-dependent cardiotoxicity. Moreover, there …

Induction of cytochrome P450 CYP2E1 by ethanol appears to be one of the mechanisms by
which ethanol creates a state of oxidative stress. Glutathione (GSH) is a key cellular …

Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)–
derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome …

Cytochrome P450 2J2 isoform (CYP2J2) is a drug-metabolizing enzyme that is highly
expressed in adult ventricular myocytes. It is responsible for the bioactivation of arachidonic …

Diets high in polyunsaturated fatty acids (PUFA) are important for the development of
alcoholic liver injury. The goal of this report was to characterize toxicity by arachidonic acid …

Midazolam (MDZ) and triazolam (TRZ) hydroxylation, reactions considered to be cytochrome
P-4503A (CYP3A)-mediated in humans, were examined in mouse and human liver …

Abstract Hepatocytes isolated from Sprague–Dawley rats were incubated with various
concentrations of either amiodarone or desethylamiodarone fro 0 to 69 hr. Both drugs …

Background—Oxidative stress plays an important role in the pathophysiology of ischemic
heart disease and heart failure, and antioxidants might be beneficial in the treatment of …

Several antihistamine drugs including terfenadine, ebastine, and astemizole have been
identified as substrates for CYP2J2. The overall importance of this enzyme in drug …