Sodium salicylate increases CYP2E1 levels and enhances arachidonic acid toxicity in HepG2 cells and cultured rat hepatocytes
D Wu, AI Cederbaum - Molecular pharmacology, 2001 - ASPET
Sodium salicylate and acetylsalicylic acid are drugs used as anti-inflammatory agents.
Salicylate prevents nuclear factor-κB activation and can cause apoptosis. However …
Salicylate prevents nuclear factor-κB activation and can cause apoptosis. However …
Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats
BNM Zordoky, A Anwar-Mohamed, ME Aboutabl… - Toxicology and applied …, 2010 - Elsevier
Doxorubicin (DOX) is a potent anti-neoplastic antibiotic used to treat a variety of
malignancies; however, its use is limited by dose-dependent cardiotoxicity. Moreover, there …
malignancies; however, its use is limited by dose-dependent cardiotoxicity. Moreover, there …
Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 …
M Marı́, J Bai, AI Cederbaum - Journal of Pharmacology and Experimental …, 2002 - ASPET
Induction of cytochrome P450 CYP2E1 by ethanol appears to be one of the mechanisms by
which ethanol creates a state of oxidative stress. Glutathione (GSH) is a key cellular …
which ethanol creates a state of oxidative stress. Glutathione (GSH) is a key cellular …
Cytochrome P450 2J2: potential role in drug metabolism and cardiotoxicity
M Solanki, A Pointon, B Jones, K Herbert - Drug Metabolism and Disposition, 2018 - ASPET
Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)–
derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome …
derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome …
CYP2J2 expression in adult ventricular myocytes protects against reactive oxygen species toxicity
EA Evangelista, RN Lemaitre, N Sotoodehnia… - Drug Metabolism and …, 2018 - ASPET
Cytochrome P450 2J2 isoform (CYP2J2) is a drug-metabolizing enzyme that is highly
expressed in adult ventricular myocytes. It is responsible for the bioactivation of arachidonic …
expressed in adult ventricular myocytes. It is responsible for the bioactivation of arachidonic …
Cyclosporine A protects against arachidonic acid toxicity in rat hepatocytes: role of CYP2E1 and mitochondria
D Wu, AI Cederbaum - Hepatology, 2002 - journals.lww.com
Diets high in polyunsaturated fatty acids (PUFA) are important for the development of
alcoholic liver injury. The goal of this report was to characterize toxicity by arachidonic acid …
alcoholic liver injury. The goal of this report was to characterize toxicity by arachidonic acid …
Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms
MD Perloff, LL von Moltke, T Kotegawa… - … of Pharmacology and …, 2000 - ASPET
Midazolam (MDZ) and triazolam (TRZ) hydroxylation, reactions considered to be cytochrome
P-4503A (CYP3A)-mediated in humans, were examined in mouse and human liver …
P-4503A (CYP3A)-mediated in humans, were examined in mouse and human liver …
Amiodarone–and Desethylamiodarone–Induced Myelinoid Inclusion Bodies and Toxicity Cultured Rat Hepatocytes
P Somani, S Bandyopadhyay, JE Klaunig, SA Gross - Hepatology, 1990 - journals.lww.com
Abstract Hepatocytes isolated from Sprague–Dawley rats were incubated with various
concentrations of either amiodarone or desethylamiodarone fro 0 to 69 hr. Both drugs …
concentrations of either amiodarone or desethylamiodarone fro 0 to 69 hr. Both drugs …
Amiodarone protects cardiac myocytes against oxidative injury by its free radical scavenging action
T Ide, H Tsutsui, S Kinugawa, H Utsumi, A Takeshita - Circulation, 1999 - Am Heart Assoc
Background—Oxidative stress plays an important role in the pathophysiology of ischemic
heart disease and heart failure, and antioxidants might be beneficial in the treatment of …
heart disease and heart failure, and antioxidants might be beneficial in the treatment of …
Identification of novel substrates for human cytochrome P450 2J2
CA Lee, D Neul, A Clouser-Roche, D Dalvie… - Drug metabolism and …, 2010 - ASPET
Several antihistamine drugs including terfenadine, ebastine, and astemizole have been
identified as substrates for CYP2J2. The overall importance of this enzyme in drug …
identified as substrates for CYP2J2. The overall importance of this enzyme in drug …