Mineralization of fibrillar collagen with biomimetic process-directing agents has enabled
scientists to gain insight into the potential mechanisms involved in intrafibrillar …

Contemporary models of intrafibrillar mineralization mechanisms are established using
collagen fibrils as templates without considering the contribution from collagen-bound …

The critical role of the self-assembled structure of collagen in skeletal mineralization is long
recognized, yet the angstrom to tens of nanometers length-scale nucleation mechanism of …

Biomineralization in vertebrates is a ubiquitous and tightly regulated process which creates
hierarchical structures for the skeleton. Because of the lack of understanding and …

Polyelectrolytes such as polyaspartic acid (PAsp) are critical in biomimetic mineralization as
stabilizers of amorphous calcium phosphate (ACP) precursors and as nucleation inhibitors …

Involvement of thermodynamically-stable prenucleation clusters (PNCs) in the
biomineralization of collagen has been speculated since their existence was reported in …

Bone is a hierarchically structured composite material whose basic building block is the
mineralized collagen fibril, where the collagen is the scaffold into which the hydroxyapatite …

Hydroxyapatite (HA) reinforced collagen fibrils serve as the basic building blocks of natural
bone and dentin. Mineralization of collagen fibrils play an essential role in ensuring the …

Biomineralisation of collagen involves functional motifs incorporated in extracellular matrix
protein molecules to accomplish the objectives of stabilising amorphous calcium phosphate …

Apatite–collagen composites belong to the most abundant biominerals in both humans and
animal life forms. The importance of this material as the predominant component of bone …