Alzheimer's disease (AD) is one of the major disabling and lethal diseases for aged
individuals worldwide. To date, there are more than 10 hypotheses proposed for AD …

Aberrant amyloid-β peptide (Aβ) accumulation along with altered expression and function of
nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's …

Alzheimer's disease (AD) is a neurodegenerative condition characterized by increased
accumulation of Aβ and degeneration of cholinergic signaling between basal forebrain and …

The nicotinic receptors (nAChRs), which play a critical role in cognitive function, are
impaired early in the course of Alzheimer's disease (AD). We have previously demonstrated …

It has been recently shown that the Alzheimer's disease (AD) pathogenic peptide amyloid β1–
42 (Aβ1–42) binds to the α7 nicotinic acetylcholine receptor (α7nAChR) with high affinity …

The accumulation of amyloid-beta peptide (Aβ) and the failure of cholinergic transmission
are key players in Alzheimer's disease (AD). However, in the healthy brain, Aβ contributes to …

We previously reported that α7 nicotinic acetylcholine receptor (nAChR) agonism produces
efficacy in preclinical cognition models correlating with activation of cognitive and …

Alzheimer's Disease (AD) is the most common of the senile dementias, the prevalence of
which is increasing rapidly, with a projected 14 million affected worldwide by 2025. The …

Background β-amyloid (Aβ) accumulation is described as a hallmark of Alzheimer's disease
(AD). Aβ perturbs a number of synaptic components including nicotinic acetylcholine …

One of the early signs of Alzheimer's disease is the impairment in hippocampus-based
episodic memory function, which is improved through the enhancement of cholinergic …