Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas systems are well-
known acquired immunity systems that are widespread in archaea and bacteria. The RNA …

The constant selective pressure exerted by phages, the viruses that infect bacteria, has led
to the evolution of a wide range of anti-phage defenses. One of these defense mechanisms …

CRISPR–Cas systems constitute the adaptive immune system of bacteria and archaea, as a
sequence-specific nucleic acid targeting defense mechanism. The sequence-specific …

The last decade has seen the fields of molecular biology and genetics transformed by the
development of CRISPR-based gene editing technologies. These technologies were …

Genome editing technologies have been revolutionized by the discovery of prokaryotic RNA-
guided defense system called CRISPR-Cas. Cas9, a single effector protein found in type II …

Class 2 CRISPR–Cas systems are characterized by effector modules that consist of a single
multidomain protein, such as Cas9 or Cpf1. We designed a computational pipeline for the …

CRISPR-Cas technologies have greatly reshaped the biology field. In this review, we
discuss the CRISPR-Cas with a particular focus on the associated technologies and …

The development of clustered regularly interspaced short-palindromic repeat (CRISPR)-Cas
systems for genome editing has transformed the way life science research is conducted and …

CRISPR-Cas constitutes the adaptive immune system of bacteria and archaea. This RNA-
mediated sequence-specific recognition and targeting machinery has been used broadly for …

CRISPR–Cas systems of bacteria and archaea comprise chromosomal loci with typical
repetitive clusters and associated genes encoding a range of Cas proteins. Adaptation of …