Plasmodium knowlesi occurs throughout Southeast Asia, and is the most common cause of
human malaria in Malaysia. Severe disease in humans is characterised by high parasite …

Background Pathogenesis of severe Plasmodium vivax malaria is poorly understood.
Endothelial dysfunction and reduced nitric oxide (NO) bioavailability characterize severe …

Severe falciparum malaria (SM) is associated with tissue ischemia related to cytoadherence
of parasitized erythrocytes to microvascular endothelium and reduced levels of NO and its …

Adherence of parasitized erythrocytes to activated endothelium causes microvascular
obstruction, tissue ischemia, and clinical complications in severe malaria (SM); however, the …

Background Microvascular obstruction and endothelial dysfunction have both been linked to
tissue hypoperfusion in falciparum malaria, but their relative contributions to the disease's …

Plasmodium vivax can cause severe malaria, however its pathogenesis is poorly
understood. In contrast to P. falciparum, circulating vivax parasitemia is low, with minimal …

Endothelial activation and microvascular dysfunction are key pathogenic processes in
severe malaria. We evaluated the early role of these processes in experimentally induced …

Background. In populations pauci-immune to malaria, risk of severe malaria increases with
age. This is particularly apparent in Plasmodium knowlesi malaria. However …

Background Acute kidney injury (AKI) complicating severe Plasmodium falciparum malaria
occurs in up to 40% of adult patients. The case fatality rate reaches 75% in the absence of …

Background Hemolysis causes anemia in falciparum malaria, but its contribution to
microvascular pathology in severe malaria (SM) is not well characterized. In other hemolytic …