Update on the chondrocyte lineage and implications for cell therapy in osteoarthritis

MB Goldring - … : A Companion to Rheumatology. Philadelphia (PA …, 2007 - books.google.com
Chondrocytes serve diverse functions during development and postnatal life and are the
single cellular component of the articular cartilage of diarthrodial joints. During skeletal …

Stem cell-directed therapies for osteoarthritis: the promise and the practice

J Ng, CB Little, S Woods, S Whittle, FY Lee… - Stem …, 2020 - academic.oup.com
Osteoarthritis (OA) is a disease of an entire synovial joint characterized by clinical symptoms
and distortion of joint tissues, including cartilage, muscles, ligaments, and bone. Although …

Update on the biology of the chondrocyte and new approaches to treating cartilage diseases

MB Goldring - Best practice & research Clinical rheumatology, 2006 - Elsevier
Osteoarthritis (OA) is a joint disease that involves degeneration of articular cartilage, limited
intraarticular inflammation manifested by synovitis and changes in the subchondral bone …

Stem cells in osteoarthritis

VM Goldberg - 2012 - journals.sagepub.com
Articular cartilage has significant limitations for repair or regeneration. It does not respond to
an injury or disease with the normal inflammatory sequence of events that results in repair of …

Osteoarthritis: a cellular differentiation defect?

T Kirsch - Current Opinion in Orthopaedics, 2003 - journals.lww.com
Purpose of review: Osteoarthritis is the most common form of arthritis, affecting a large
population of mostly elderly people. No cure for osteoarthritis currently exists. Ultimate …

Stem cell therapy for cartilage regeneration in osteoarthritis

S Koelling, N Miosge - Expert opinion on biological therapy, 2009 - Taylor & Francis
Enhancing the regeneration potential of hyaline cartilage tissue remains a great challenge.
During embryonic development, some of the cells of the inner cell mass will turn into the …

Role of crosstalk between synovial cells and chondrocytes in osteoarthritis

B Chen, Y Sun, G Xu, J Jiang… - Experimental and …, 2024 - spandidos-publications.com
Osteoarthritis (OA) is a low‑grade, nonspecific inflammatory disease that affects the entire
joint. This condition is characterized by synovitis, cartilage erosion, subchondral bone …

[PDF][PDF] From pluripotent stem cells to lineage-specific chondrocytes: essential signalling and cellular intermediates

N Nakayama, K Umeda - Embryonic stem cells: the …, 2011 - openresearchlibrary.org
Cartilage is a type of connective tissue found throughout the body. The three major types of
cartilage are distinguished by their physical properties, which reflect their relative contents of …

The role of progenitor cells in osteoarthritis

J Kruegel, N Miosge, S Koelling - Current Rheumatology …, 2008 - ingentaconnect.com
It remains a great challenge to enhance the regeneration potential of hyaline cartilage
tissue. Tissue degeneration activities initiated after major injury or due to age-related …

The role of progenitor cells in osteoarthritis development and progression

L Labusca, K Mashayekhi - Current Stem Cell Research & …, 2015 - ingentaconnect.com
Osteoarthritis (OA) is the most common degenerative joint disorder worldwide. OA
represents an increasing threat to the quality of life of affected persons as well as for health …