Predicting potential miRNA target sites within gene promoters
Synthetic small duplex RNAs that are complementary to gene promoters can activate or
inhibit target gene expression. The potency and robustness of gene modulation by these …
inhibit target gene expression. The potency and robustness of gene modulation by these …
Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters
ST Younger, DR Corey - Nucleic acids research, 2011 - academic.oup.com
Synthetic small duplex RNAs that are fully complementary to gene promoters can silence
transcription in mammalian cells. microRNAs (miRNAs) are endogenous small regulatory …
transcription in mammalian cells. microRNAs (miRNAs) are endogenous small regulatory …
Transcriptional regulation by miRNA mimics that target sequences downstream of gene termini
ST Younger, DR Corey - Molecular BioSystems, 2011 - pubs.rsc.org
Transcriptome studies have revealed that protein-coding loci within the human genome are
overlapped at their 3′-termini by noncoding RNA (ncRNA) transcripts. Small duplex RNAs …
overlapped at their 3′-termini by noncoding RNA (ncRNA) transcripts. Small duplex RNAs …
A novel method to detect functional microRNA targets
S Vatolin, K Navaratne, RJ Weil - Journal of molecular biology, 2006 - Elsevier
MicroRNA (miRNA) molecules are non-coding RNAs, 19 to 24nt in length that have been
identified recently as important regulators of gene expression. Several computational …
identified recently as important regulators of gene expression. Several computational …
Passenger strand loading in overexpression experiments using microRNA mimics
MicroRNAs (miRNAs) are important regulators of gene function and manipulation of miRNAs
is a central component of basic research. Modulation of gene expression by miRNA gain-of …
is a central component of basic research. Modulation of gene expression by miRNA gain-of …
Desperately seeking microRNA targets
M Thomas, J Lieberman, A Lal - Nature structural & molecular biology, 2010 - nature.com
MicroRNAs (miRNAs) suppress gene expression by inhibiting translation, promoting mRNA
decay or both. Each miRNA may regulate hundreds of genes to control the cell's response to …
decay or both. Each miRNA may regulate hundreds of genes to control the cell's response to …
Conserved expression patterns predict microRNA targets
W Ritchie, M Rajasekhar, S Flamant… - PLoS computational …, 2009 - journals.plos.org
microRNAs (miRNAs) are major regulators of gene expression and thereby modulate many
biological processes. Computational methods have been instrumental in understanding how …
biological processes. Computational methods have been instrumental in understanding how …
MicroRNAs: key participants in gene regulatory networks
XS Ke, CM Liu, DP Liu, CC Liang - Current opinion in chemical biology, 2003 - Elsevier
microRNAs (miRNAs) are a newly identified and surprisingly large class of endogenous tiny
regulatory RNAs. They exhibit various expressional patterns and are highly conserved …
regulatory RNAs. They exhibit various expressional patterns and are highly conserved …
LNA-modified oligonucleotides mediate specific inhibition of microRNA function
microRNAs are short, endogenous non-coding RNAs that act as post-transcriptional
modulators of gene expression. Important functions for microRNAs have been found in the …
modulators of gene expression. Important functions for microRNAs have been found in the …
Unraveling the determinants of microRNA mediated regulation using a massively parallel reporter assay
I Vainberg Slutskin, S Weingarten-Gabbay… - Nature …, 2018 - nature.com
Despite extensive research, the sequence features affecting microRNA-mediated regulation
are not well understood, limiting our ability to predict gene expression levels in both native …
are not well understood, limiting our ability to predict gene expression levels in both native …