Early detection of Alzheimer's disease with PET imaging

V Berti, RS Osorio, L Mosconi, Y Li, S De Santi… - Neurodegenerative …, 2010 - karger.com
Preclinical diagnosis of Alzheimer's disease (AD) is one of the major challenges for the
prevention of AD. AD biomarkers are needed not only to reveal preclinical pathologic …

FDG-PET and amyloid-PET imaging: the diverging paths

D Perani - Current Opinion in Neurology, 2014 - journals.lww.com
The different molecular paths that PET in-vivo biomarkers can reveal in the timeframe of
Alzheimer's disease progression reflect the events leading to deposition of Aβ and …

PET imaging for early detection of Alzheimer's disease: from pathologic to physiologic biomarkers

W Bao, H Jia, S Finnema, Z Cai, RE Carson… - PET clinics, 2017 - pet.theclinics.com
Alzheimer's disease (AD) affects more than 35 million people worldwide, and the number is
estimated to quadruple in 40 years if there remains no cure. 1–4 AD is characterized by the …

Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment

A Chandra, PE Valkimadi, G Pagano… - Human brain …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is a devastating and progressive neurodegenerative disease for
which there is no cure. Mild cognitive impairment (MCI) is considered a prodromal stage of …

Amyloid imaging

VL Villemagne, CC Rowe - International psychogeriatrics, 2011 - cambridge.org
Molecular neuroimaging techniques such as PET are proving valuable in the early and
differential diagnosis of Alzheimer's disease (AD). With the advent of new therapeutic …

[HTML][HTML] PET amyloid-beta imaging in preclinical Alzheimer's disease

AG Vlassenko, TLS Benzinger, JC Morris - Biochimica et Biophysica Acta …, 2012 - Elsevier
Alzheimer's disease (AD) is the leading cause of dementia, accounting for 60–70% of all
cases [Hebert et al., 2003, 1]. The need for effective therapies for AD is great. Current …

A survey of FDG‐and amyloid‐PET imaging in dementia and GRADE analysis

P Daniela, S Orazio, P Alessandro… - BioMed research …, 2014 - Wiley Online Library
PET based tools can improve the early diagnosis of Alzheimer's disease (AD) and
differential diagnosis of dementia. The importance of identifying individuals at risk of …

[HTML][HTML] FDG-and amyloid-PET in Alzheimer's disease: Is the whole greater than the sum of the parts?

L Mosconi, PF McHugh - The Quarterly Journal of Nuclear Medicine …, 2011 - ncbi.nlm.nih.gov
The development of prevention therapies for Alzheimer's disease (AD) would greatly benefit
from biomarkers that are sensitive to subtle brain changes occurring prior to the onset of …

The role of positron emission tomography imaging in understanding Alzheimer's disease

H Barthel, J Seibyl, O Sabri - Expert Review of Neurotherapeutics, 2015 - Taylor & Francis
PET is a non-invasive imaging technique which allows the visualization and quantification of
molecular processes, offering sensitive and early disease detection. Alzheimer's disease …

Alzheimer's dementia: the emerging role of positron emission tomography

SM Tripathi, AD Murray - The Neuroscientist, 2022 - journals.sagepub.com
Alzheimer's disease (AD) is the most common cause of dementia and accounts for
approximately 50% to 80% of all cases of dementia. The diagnosis of probable AD is based …