Tumor associated angiogenesis is the development of new blood vessels in response to
proteins secreted by tumor cells. These new blood vessels allow tumors to continue to grow …

Inhibition of VEGF signalling effectively suppresses localized tumour growth but accelerates
tumour invasiveness and micrometastasis by unknown mechanisms. To study the dynamic …

Tumors exploit angiogenesis, the formation of new blood vessels from pre-existing
vasculature, in order to obtain nutrients required for continued growth and proliferation …

Intravasation and extravasation of cancer cells through blood/lymph vessel endothelium are
essential steps during metastasis. Successful invasion requires coordinated tumor …

Background The cancer microenvironment has a strong impact on the growth and dynamics
of cancer cells. Conventional 2D culture systems, however, do not reflect in vivo conditions …

The metastasis in which the cancer cells degrade the extracellular matrix (ECM) and invade
to the surrounding and far tissues of the body is the leading cause of mortality in cancer …

Tumors have been thought to initiate as avascular aggregates of malignant cells that only
later induce vascularization. Recently, this classic concept of tumor angiogenesis has been …

Modeling interstitial fluid flow involves processes such as fluid diffusion, convective transport
in the extracellular matrix, and extravasation from blood vessels. In all of these processes …

Tumor neovascularization is a highly complex process including multiple steps.
Understanding this process, especially the initial stage, has been limited by the difficulties of …

Heterogeneity is a characteristic feature of solid tumors. Intra-tumor heterogeneity includes
phenotypic diversity, epigenetic abnormalities, cell proliferation, and plasticity that eventually …