Asthma is a chronic inflammatory disease of the respiratory tract. This heterogeneous
disease is caused by the interaction of interindividual genetic variability and environmental …

Atopic asthma, which is characterized by the chronic inflammation and morbidity of airways,
is a disease of great complexity, and multiple genetic and environmental factors are involved …

Our objective was to investigate the distributions of six single nucleotide polymorphisms
(SNPs) MS4A2 E237G, MS4A2 C-109T, ADRB2 R16G, IL4RA I75V, IL4 C-590T, and IL13 …

Recent genome-wide association studies (GWAs) have identified several new genetic risk
factors for asthma; however, their influence on disease behavior and treatment response is …

Polymorphisms in the promoter region of CD14 gene have been associated with asthma
and atopy although the findings between cohorts have not been uniform. We aimed at …

In asthma, the response to β-agonists acting at β2-adrenergic receptors (β2AR) displays
extensive interindividual variation. One effector for airway β2AR, adenylyl cyclase type 9 …

Background Asthma is a complex disease characterized by hyperresponsiveness,
obstruction and inflammation of the airways. To date, several studies using different …

Background/Aim: The molecular mechanisms underlying the association between cell cycle
and asthma are poorly understood, and cyclin D1 (CCND1) is found to be upregulated in …

Adenylyl cyclase (AC) mediates signalling following activation of G αs-coupled receptors
such as the β 2-adrenergic receptor (β 2 AR). Genetic variation in the receptor component of …

Asthma is a heterogeneous disease associated with a complex basis involving
environmental factors and individual variabilities. The DENN Domain Containing 1B …