Rationale: Prior sepsis studies evaluating antibiotic timing have shown mixed results.
Objectives: To evaluate the association between antibiotic timing and mortality among …

Objectives: Compelling evidence has shown that aggressive resuscitation bundles,
adequate source control, appropriate antibiotic therapy, and organ support are cornerstone …

OBJECTIVES: Rapid delivery of antibiotics is a cornerstone of sepsis therapy, although time
targets for specific components of antibiotic delivery are unknown. We quantified time …

Objectives: We sought to systematically review and meta-analyze the available data on the
association between timing of antibiotic administration and mortality in severe sepsis and …

Objective: We sought to determine the association between time to initial antibiotics and
mortality of patients with septic shock treated with an emergency department-based early …

Objective: To evaluate the association between total medical contact, prehospital, and
emergency department delays in antibiotic administration and in-hospital mortality among …

Background The impact of antibiotic timing on sepsis outcomes remains controversial due to
conflicting results from previous studies. Objectives This study investigated the association …

Objectives To review the impact of the timeliness of antibiotic therapy on the outcome of
patients with sepsis or septic shock. Methods We searched MEDLINE, EMBASE, the …

Background Influential studies conclude that each hour until antibiotics increases mortality in
sepsis. However, these analyses often (1) adjusted for limited covariates,(2) included …

Background In 2013, New York began requiring hospitals to follow protocols for the early
identification and treatment of sepsis. However, there is controversy about whether more …