High anxiety levels and heightened stress are important factors for cocaine maintenance,
reinforcing, and relapse. Chronic cocaine is known to result in a high prevalence of anxiety …

Anecdotal and epidemiological reports, as well as findings from clinical and preclinical
animal laboratory studies, point to stress as a significant contributor to cocaine addiction …

Heightened anxiety and sensitivity to stress following chronic cocaine use are likely to
increase an individual's susceptibility for relapse to drug-seeking behavior. Thus, it is …

Adolescents display increased vulnerability to engage in drug experimentation. This is often
considered a risk factor for later drug abuse. In this scenario, the permanent effects of …

Cocaine is an addictive psychomotor stimulant that produces a number of subjective and
behavioral effects, such as intense euphoria, acute psychosis, and epileptiform seizures as …

The ability of stressful life events to trigger drug use is particularly problematic for the
management of cocaine addiction due to the unpredictable and often uncontrollable nature …

The hypothalamo-pituitary-adrenal (HPA) axis is involved in all aspects of cocaine self-
administration. Corticosterone seems to be crucial for the acquisition of drug use since self …

The initial termination of cocaine consumption in human addicts is associated with
heightened anxiety states and low levels of craving. Craving, however, tends to increase …

Background Cocaine dependence is associated with high rates of relapse. Stress and drug
cue exposure are known to increase cocaine craving and stress arousal, but the association …

This study highlights respondent sensitivity to daily hassles as it relates to situational
cocaine use and perceived long-term effects of adverse events in childhood. Data were …