Synergistic drug combinations can extend the use of poly (ADP-ribose) polymerase
inhibitors (PARPi) such as Olaparib to BRCA-proficient tumors and overcome acquired or de …

Organometallic ruthenium (II) arene complexes containing the PTA ligand ([Ru (η6-arene)
Cl2 (PTA)], PTA= 1, 3, 5-triaza-7-phosphatricyclo-[3.3. 1.1] decane, termed RAPTA) show …

GLOBOCAN 2012 estimates 14.1 million new cancer cases and 8.2 million cancer-related
deaths worldwide. Cancer is rapidly becoming a major public health concern in India as …

This paper reports the synthesis, structure characterization, and anticancer properties of 13
organometallic Ru (II)–arene complexes:[Ru (η6-p-cymene) Cl-(L1)](1),[Ru (η6-p-cymene) …

Colorectal cancer (CRC) is one of the most common malignancies and one of the leading
causes of cancer-related death worldwide, urging the need for new and more efficient …

Although different types of metal-based anticancer complexes have been synthesized, novel
complexes to reduce the serious side effect of cisplatin and conquer cancer metastasis are …

We report on the synthesis of novel water-soluble [(arene) RuII (Q) Cl] and [(arene) RuII
(Q)(X)] BF4 compounds (arene= p-cymene, benzene, hexamethylbenzene; HQ= 1, 3 …

The synthesis and full characterization of new half-sandwich ruthenium (II) complexes
containing κ3 (N, N, N)-hydridotris (pyrazolyl) borate (κ3 (N, N, N)-Tp) and the water-soluble …

Due to these limitations of platinum-based drugs, it has now become a challenge for
researchers to find out a potential scaffold furnished with indispensable properties like …

Background: The RAPTA-EA1 complex [ruthenium (II)-arene 1, 3, 5-triaza-7-
phosphaadamantane (pta) complex with an arene-tethered ethacrynic acid ligand] has been …