3, 3′-Diindolylmethane induces anti-human gastric cancer cells by the miR-30e-ATG5 modulating autophagy
Y Ye, Y Fang, W Xu, Q Wang, J Zhou, R Lu - Biochemical pharmacology, 2016 - Elsevier
Diindolylmethane (DIM), a class of relatively non-toxic indole derivatives from cruciferous
vegetables, has been reported as a promising anticancer phytochemical, but the underlying …
vegetables, has been reported as a promising anticancer phytochemical, but the underlying …
Cellular and molecular mechanisms of 3, 3′-diindolylmethane in gastrointestinal cancer
SM Kim - International journal of molecular sciences, 2016 - mdpi.com
Studies in humans have shown that 3, 3′-diindolylmethane (DIM), which is found in
cruciferous vegetables, such as cabbage and broccoli, is effective in the attenuation of …
cruciferous vegetables, such as cabbage and broccoli, is effective in the attenuation of …
[HTML][HTML] Anti-cancer drug 3, 3′-diindolylmethane activates Wnt4 signaling to enhance gastric cancer cell stemness and tumorigenesis
Y Zhu, B Zhang, A Gong, H Fu, X Zhang, H Shi, Y Sun… - Oncotarget, 2016 - ncbi.nlm.nih.gov
As a natural health supplement, 3, 3′-diindolylmethane (DIM) is proposed as a preventive
and chemotherapeutic agent for cancer by inhibiting cell proliferation and inducing cell …
and chemotherapeutic agent for cancer by inhibiting cell proliferation and inducing cell …
Modulatory effect of indoles on the expression of miRNAs regulating G1/S cell cycle phase in breast cancer cells
Abstract Indole-3-carbinol (I3C) is a naturally occurring glucosinolate found in Brassica
vegetables that is usually converted in gastric acidic environment to the efficient metabolite …
vegetables that is usually converted in gastric acidic environment to the efficient metabolite …
3, 3'-Diindolylmethane potentiates paclitaxel-induced antitumor effects on gastric cancer cells through the Akt/FOXM1 signaling cascade
H Jin, MH Park, SM Kim - Oncology reports, 2015 - spandidos-publications.com
Gastric cancer is the fourth most common cancer and is one of the leading causes of cancer-
related mortality worldwide. Forkhead box M1 (FOXM1) is overexpressed in gastric cancer …
related mortality worldwide. Forkhead box M1 (FOXM1) is overexpressed in gastric cancer …
3, 3'-Diindolylmethane inhibits patient-derived xenograft colon tumor growth by targeting COX1/2 and ERK1/2
X Tian, KD Liu, X Zu, F Ma, Z Li, MH Lee, H Chen, Y Li… - Cancer letters, 2019 - Elsevier
Diindolymethane (DIM) is a dimeric condensation product of indole-3-carbinol (I3C) that is
found in broccoli and cabbage. Although DIM has been reported to exhibit anticancer …
found in broccoli and cabbage. Although DIM has been reported to exhibit anticancer …
Mir-30d suppresses cell proliferation of colon cancer cells by inhibiting cell autophagy and promoting cell apoptosis
R Zhang, J Xu, J Zhao, J Bai - Tumor Biology, 2017 - journals.sagepub.com
MiR-30 family plays an important role in the tumorigenesis of human cancers. The aim of the
study is to investigate the role of miR-30d in human colon cancer cell lines and explore the …
study is to investigate the role of miR-30d in human colon cancer cell lines and explore the …
[HTML][HTML] Advances in indole-containing alkaloids as potential anticancer agents by regulating autophagy
ML Luo, W Huang, HP Zhu, C Peng, Q Zhao… - Biomedicine & …, 2022 - Elsevier
Cancer is a leading cause of death worldwide, and cancer development is often associated
with disturbances in the autophagy process. Autophagy is a catabolic process involved in …
with disturbances in the autophagy process. Autophagy is a catabolic process involved in …
Celastrol upregulated ATG7 triggers autophagy via targeting Nur77 in colorectal cancer
W Zhang, Z Wu, H Qi, L Chen, T Wang, X Mao, H Shi… - Phytomedicine, 2022 - Elsevier
Background Celastrol is a biologically active ingredient extracted from Tripterygium wilfordii
that has exerted properties of anti-cancer. We explored the anti-tumor activities of celastrol …
that has exerted properties of anti-cancer. We explored the anti-tumor activities of celastrol …
Induction of G1 and G2/M cell cycle arrests by the dietary compound 3, 3'-diindolylmethane in HT-29 human colon cancer cells
HJ Choi, DY Lim, JHY Park - BMC gastroenterology, 2009 - Springer
Abstract Background 3, 3'-Diindolylmethane (DIM), an indole derivative produced in the
stomach after the consumption of broccoli and other cruciferous vegetables, has been …
stomach after the consumption of broccoli and other cruciferous vegetables, has been …