The human gut microbiota is known for its pharmaceutical biotransformation capabilities.
Many pharmaceuticals are fluorinated; however, it was previously unknown whether gut …

The capacity to defluorinate polyfluorinated organic compounds is a rare phenotype in
microbes but is increasingly considered important for maintaining the environment. New …

Regarding the emerging concerns of the widely occurred and environmentally persistent per-
and polyfluoroalkyl substances (PFASs), one intriguing and unsolved scientific question for …

The introduction of fluorine atoms into organic molecules has received considerable
attention as these organofluorines have often found widespread applications in bioorganic …

Enzymatic cleavage of C—F bonds in per–and polyfluoroalkyl substances (PFAS) is largely
unknown but avidly sought to promote systems biology for PFAS bioremediation. Here, we …

Per-and polyfluoroalkyl substances (PFAS) are toxic compounds linked to cancers, infertility,
and vaccine resistance at concentrations above 1 part per trillion. Owing to strong carbon …

Fluorinated organic chemicals, such as per-and polyfluorinated alkyl substances (PFAS)
and fluorinated pesticides, are both broadly useful and unusually long-lived. To combat …

Enzymatic cleavage of C─ F bonds in per-and polyfluoroalkyl substances (PFAS) is largely
unknown but avidly sought to promote systems biology for PFAS bioremediation. Here, we …

The carbon− fluorine bond is the strongest covalent bond in organic chemistry, yet
fluoroacetate dehalogenases can readily hydrolyze this bond under mild physiological …

Fluorine forms the strongest single bond to carbon with the highest bond dissociation energy
among natural products. However, fluoroacetate dehalogenases (FADs) have been shown …