Age-related macular degeneration 1969–2004: a 35-year personal perspective

SL Fine - American journal of ophthalmology, 2005 - Elsevier
PURPOSE: To provide a personal perspective concerning diagnosis, treatment, and
evaluation of treatment for early and late stages of age-related macular degeneration (AMD) …

Age-related macular degeneration: a review of experimental treatments

TA Ciulla, RP Danis, A Harris - Survey of ophthalmology, 1998 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in
the USA. Laser photocoagulation of choroidal neovascular membranes (CNVMs) in …

Age related macular degeneration and drusen: neuroinflammation in the retina

E Buschini, A Piras, R Nuzzi, A Vercelli - Progress in neurobiology, 2011 - Elsevier
Inflammation protects from dangerous stimuli, restoring normal tissue homeostasis.
Inflammatory response in the nervous system (“neuroinflammation”) has distinct features …

Animal models of age-related macular degeneration and their translatability into the clinic

S Chen, NA Popp, CC Chan - Expert review of ophthalmology, 2014 - Taylor & Francis
Age-related macular degeneration (AMD) is a leading cause of blindness in people over the
age of 55. Despite its common nature, the etiology of the disease involves both genetic and …

Genetics and genetic testing for age-related macular degeneration

A Warwick, A Lotery - Eye, 2018 - nature.com
Considerable advances have been made in our understanding of age-related macular
degeneration (AMD) genetics over the past decade. The genetic associations discovered to …

[HTML][HTML] Epigenetics in age-related macular degeneration: new discoveries and future perspectives

M Gemenetzi, AJ Lotery - Cellular and Molecular Life Sciences, 2020 - Springer
The study of epigenetics has explained some of the 'missing heritability'of age-related
macular degeneration (AMD). The epigenome also provides a substantial contribution to the …

Progress in defining the molecular biology of age related macular degeneration

A Lotery, D Trump - Human genetics, 2007 - Springer
Age related macular degeneration (AMD) is an extremely prevalent complex genetic
disorder. Its incidence rises exponentially in the elderly to a frequency of 1 in 2 in the …

[HTML][HTML] Exploring the pathogenesis of age-related macular degeneration: A review of the interplay between retinal pigment epithelium dysfunction and the innate …

JHC Wong, JYW Ma, AI Jobling, A Brandli… - Frontiers in …, 2022 - frontiersin.org
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the
older population. Classical hallmarks of early and intermediate AMD are accumulation of …

[HTML][HTML] Regulation of signaling events involved in the pathophysiology of neovascular AMD

H Wang, ME Hartnett - Molecular vision, 2016 - ncbi.nlm.nih.gov
Neovascular age-related macular degeneration (AMD) is a complex disease in which an
individual's genetic predisposition is affected by aging and environmental stresses, which …

Neovascular age-related macular degeneration

J Shao, MM Choudhary, AP Schachat - Retinal Pharmacotherapeutics, 2016 - karger.com
Age-related macular degeneration (AMD) is the leading cause of severe vision loss in
individuals over the age of 50 years. Choroidal neovascularization (CNV) is the hallmark of …