Latency-associated DNA methylation patterns among HIV-1 infected individuals with distinct disease progression courses or antiretroviral virologic response
DNA methylation is one of the epigenetic modifications that configures gene transcription
programs. This study describes the DNA methylation profile of HIV-infected individuals with …
programs. This study describes the DNA methylation profile of HIV-infected individuals with …
Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals
Epigenetic control of human immunodeficiency virus-1 (HIV-1) genes is critical for viral
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …
Effect of HIV infection and antiretroviral therapy initiation on genome-wide DNA methylation patterns
A Esteban-Cantos, J Rodríguez-Centeno, JC Silla… - …, 2023 - thelancet.com
Background Previous epigenome-wide association studies have shown that HIV infection
can disrupt the host DNA methylation landscape. However, it remains unclear how …
can disrupt the host DNA methylation landscape. However, it remains unclear how …
Effects of highly active antiretroviral therapy initiation on epigenomic DNA methylation in persons living with HIV
J Zhang, ME Sehl, R Shih, EC Breen, F Li… - Frontiers in …, 2024 - frontiersin.org
Introduction: Highly active antiretroviral therapy (HAART) helps improve some measures of
accelerated epigenetic aging in persons living with HIV (PLWH), but its overall impact on the …
accelerated epigenetic aging in persons living with HIV (PLWH), but its overall impact on the …
Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART
MJ Corley, C Sacdalan, APS Pang, N Chomchey… - PLoS …, 2021 - journals.plos.org
HIV-1 disrupts the host epigenetic landscape with consequences for disease pathogenesis,
viral persistence, and HIV-associated comorbidities. Here, we examined how soon after …
viral persistence, and HIV-associated comorbidities. Here, we examined how soon after …
Deciphering DNA methylation in HIV infection
T Arumugam, U Ramphal, T Adimulam… - Frontiers in …, 2021 - frontiersin.org
With approximately 38 million people living with HIV/AIDS globally, and a further 1.5 million
new global infections per year, it is imperative that we advance our understanding of all …
new global infections per year, it is imperative that we advance our understanding of all …
Challenges in quantifying cytosine methylation in the HIV provirus
ABSTRACT DNA methylation is an epigenetic mechanism most commonly associated with
transcriptional repression. While it is clear that DNA methylation can silence HIV proviral …
transcriptional repression. While it is clear that DNA methylation can silence HIV proviral …
Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals
Background The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the
promoter and intragenic regions. DNA methylation in the promoter region has been shown …
promoter and intragenic regions. DNA methylation in the promoter region has been shown …
The Genome-wide Methylation Profile of CD4+ T Cells From Individuals With Human Immunodeficiency Virus (HIV) Identifies Distinct Patterns Associated With …
S Moron-Lopez, V Urrea, J Dalmau… - Clinical Infectious …, 2021 - academic.oup.com
Background Human genetic variation—mostly in the human leukocyte antigen (HLA) and C–
C chemokine receptor type 5 (CCR5) regions—explains 25% of the variability in progression …
C chemokine receptor type 5 (CCR5) regions—explains 25% of the variability in progression …
HIV infection alters the human epigenetic landscape
Many complex diseases or traits are the results of both genetic and environmental factors.
The environmental factors affect the human body by modifying its epigenetics, which …
The environmental factors affect the human body by modifying its epigenetics, which …
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