Better characterization of vinflunine pharmacokinetics variability and exposure/toxicity relationship to improve its use: Analyses from 18 trials

A Schmitt, L Nguyen, G Zorza, P Ferré… - British journal of …, 2018 - Wiley Online Library
Aims Vinflunine is a novel tubulin‐targeted inhibitor indicated as a single agent for the
treatment of bladder cancers after failure of prior platinum‐based therapy. Its …

Phase I and pharmacokinetic study of IV vinflunine in cancer patients with liver dysfunction

JP Delord, A Ravaud, J Bennouna, P Fumoleau… - Investigational new …, 2013 - Springer
Vinflunine is a novel tubulin-targeted agent that is currently indicated as a monotherapy in
bladder cancer patients. The recommended dose of 320 mg/m 2 is given as an intravenous …

Absolute bioavailability of an oral form of vinflunine, a first phase I trial

JP Delord, J Bennouna, E Favreau, M Brandely… - Molecular Cancer …, 2007 - AACR
Abstract C145 Background: Vinflunine (VFL) is a new microtubule inhibitor of the vinca
alkaloid class, which is active in several tumour types especially in platinum-refractory …

Vinflunine

JE Frampton, MD Moen - Drugs, 2010 - Springer
Vinflunine is a novel bifluorinated vinca alkaloid that appears to differ from other class
members in terms of its tubulin-binding properties and inhibitory effects on microtubule …

How to manage intravenous vinflunine in cancer patients with renal impairment: results of a pharmacokinetic and tolerability phase I study

N Isambert, JP Delord, JM Tourani… - British Journal of …, 2014 - Wiley Online Library
Aims Vinflunine (VFL) ditartrate, a novel tubulin‐targeted inhibitor, is registered for the
treatment of patients with advanced or metastatic urothelial transitional cell carcinoma. This …

Vinflunine oral pharmacokinetics and absolute bioavailability of soft and hard gelatin capsules: results of two phase I trials

JP Delord, J Bennouna, L Mourey, J Bougaret… - Clinical …, 2012 - Springer
Background: Vinflunine is a new-generation microtubule inhibitor, which is currently
registered in Europe and in some countries elsewhere as an intravenous formulation for the …

Influence of age on the pharmacokinetics of iv vinflunine: results of a phase I trial in elderly cancer patients

JM Tourani, L Mourey, V Servent, T Nguyen… - Journal of Geriatric …, 2012 - Elsevier
OBJECTIVE: Vinflunine (VFL) is a novel microtubule inhibitor indicated in the treatment of
advanced or metastatic urothelial transitional cell cancer after failure of a prior platinum …

[HTML][HTML] A phase II study of vinflunine in bladder cancer patients progressing after first-line platinum-containing regimen

S Culine, C Theodore, M De Santis, B Bui… - British Journal of …, 2006 - nature.com
A multicentre phase II trial to determine the efficacy of vinflunine as second-line therapy in
patients with advanced transitional cell carcinoma (TCC) of the bladder; secondary …

Real-world vinflunine outcomes in bladder cancer in a single-institution study: moving beyond clinical trials

G Moriceau, A Vallard, R Rivoirard, B Méry… - Clinical genitourinary …, 2015 - Elsevier
Purpose Intravenous vinflunine 320 mg/m 2 every 3 weeks plus best supportive care
resulted in better overall survival in comparison with best supportive care alone for eligible …

[HTML][HTML] Vinflunine in routine clinical practice for the treatment of advanced or metastatic urothelial cell carcinoma-data from a prospective, multicenter experience

M Retz, P De Geeter, PJ Goebell, U Matz, W De Schultz… - BMC cancer, 2015 - Springer
Background Vinflunine is recommended in the European guideline for the treatment of
advanced or metastatic urothelial cell carcinoma (UCC) after failure of platinum-based …