Simple Summary Cell-to-cell communication between the immune system and tumors is of
the utmost importance; it influences the development of tumors, their growth, and how they …

While immunotherapy has had an important impact on cancer treatment, only approximately
a quarter of patients respond to these treatments. Why does it work in some patients but not …

The tumor microenvironment (TME) is an integral part of cancer. Recognition of the essential
nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of …

For decades, cancer was considered a disease driven by genetic mutations in tumor cells,
therefore afflicting a single cell type. This simplified view was slowly replaced by the …

The ability of immune cells to directly interact with transformed cells is an essential
component of immune surveillance and critical for optimal tissue function. The tumor …

Understanding the spontaneous immune response of cancer patients is critical for the
design of efficient anticancer immunotherapies. The power of integrative tumor immunology …

Immunotherapy has revolutionised the treatment of cancers by harnessing the power of the
immune system to eradicate malignant tissue. However, it is well recognised that some …

Human cancers exhibit formidable molecular heterogeneity, to a large extent accounting for
the incomplete and transitory efficacy of current anti-cancer therapies. However, neoplastic …

The development of cancer has historically been attributed to genomic alterations of normal
host cells. Accordingly, the aim of most traditional cancer therapies has been to destroy the …

Accumulating evidence indicates that a dynamic cross-talk between tumors and the immune
system can regulate tumor growth and metastasis. Increased understanding of the …