CD81 expression on CD19+ peripheral blood lymphocytes is associated with chronic HCV disease and increased risk for HCV infection: a putative role for …

G D'Agosto, E Trento, L Nosotti… - Journal of Biological …, 2009 - europepmc.org
The level of CD81 cell surface expression, a cellular co-receptor for hepatitis C virus (HCV),
is critical for productive HCV infection of host cells. In addition, the cross-linking of HCV-E2 …

CD81 down-regulation on B cells is associated with the response to interferon-alpha-based treatment for chronic hepatitis C virus infection

LL Chang, PN Cheng, JS Chen, KC Young - Antiviral research, 2007 - Elsevier
The lymphocytic CD81 molecule, capable of modulating type-1/-2 T-helper responses and
serving as a putative receptor for hepatitis C virus (HCV), might influence the outcome of anti …

Interferon alfa down-regulates CD81 in patients with chronic hepatitis C

B Kronenberger, B Rüster, R Elez, S Weber, A Piiper… - Hepatology, 2001 - Elsevier
CD81 protein has been shown to bind hepatitis C virus (HCV) envelope 2 (E2) glycoprotein
in vitro and may act as a (co) receptor for HCV. Regulation of CD81 expression by interferon …

Antiviral treatment down-regulates peripheral B-cell CD81 expression and CD5 expansion in chronic hepatitis C virus infection

E Zuckerman, A Kessel, G Slobodin, E Sabo… - Journal of …, 2003 - Am Soc Microbiol
Hepatitis C virus (HCV) infection is associated with immune-mediated abnormalities and B-
cell lymphoproliferation. Recently, CD81 was identified as an HCV receptor on B …

Dynamics of CD81 expression on lymphocyte subsets during interferon-α-based antiviral treatment of patients with chronic hepatitis C

B Kronenberger, E Herrmann… - Journal of leukocyte …, 2006 - academic.oup.com
CD81 is a hepatitis C virus (HCV) coreceptor with important functions in lymphocytes. During
treatment, CD81 expression may be changed directly by the antiviral therapy or indirectly by …

CD81 expression in peripheral blood lymphocytes before and after treatment with interferon and ribavirin in HIV/HCV coinfected patients

D Micheloud, J González‐Nicolás, J Berenguer… - HIV …, 2010 - Wiley Online Library
Background CD81 is expressed on lymphocytes and confers HCV viral infectivity support.
The aim of our study was to quantify CD81 expression in peripheral blood B‐and T‐cells of …

Expansion of CD5+ B-cell overexpressing CD81 in HCV infection: towards better understanding the link between HCV infection, B-cell activation and …

E Zuckerman - Journal of hepatology, 2003 - journal-of-hepatology.eu
Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease in the
Western world affecting 1.8% of the American population and 170 million people worldwide …

CD81 nucleotide mutation in hepatocellular carcinoma and lack of CD81 polymorphism in patients at stages of hepatitis C virus infection

J Itakura, K Nagayama, N Enomoto… - Journal of medical …, 2001 - Wiley Online Library
Mechanisms determining the chronicity or the pattern of clinical course of hepatitis C virus
(HCV) infections have not been clarified. Recently, CD81 was reported to bind the E2 …

Peripheral B-cell CD5 expansion and CD81 overexpression and their association with disease severity and autoimmune markers in chronic hepatitis C virus infection

E Zuckerman, G Slobodin, A Kessel… - Clinical & …, 2002 - academic.oup.com
Hepatitis C virus (HCV) infection is associated with immune-mediated abnormalities and B-
cell lymphoproliferation evolving to an overt lymphoma. Recently, CD81 was identified as an …

Lower expression of CD81 B‐cell receptor in lymphoproliferative diseases associated with hepatitis C virus infection

P Cacoub, M Bourliere, P Hausfater… - Journal of Viral …, 2003 - Wiley Online Library
Chronic hepatitis C virus (HCV) infection is frequently associated with type II mixed
cryoglobulinaemia (MC), a benign lymphoproliferative disease (LPD). More recently, HCV …