Sphingoid bases are cytotoxic for many cancer cell lines and are thought to contribute to
suppression of intestinal tumorigenesis in vivo by ingested sphingolipids. This study …

Sphingolipids constitute a broad class of compounds with many biological functions. The
sphingolipid metabolites ceramide and sphingosine are potent apoptosis inducers and …

Modulation of sphingolipid metabolism is a promising strategy for cancer therapy that has
already opened innovative approaches for the development of pharmacological tools and …

" Sphingosin" was first described by JLW Thudichum in 1884 and structurally characterized
as 2S, 3R, 4E-2-aminooctadec-4-ene-1, 3-diol in 1947 by Herb Carter, who also proposed …

Complex dietary sphingolipids such as sphingomyelin and glycosphingolipids have been
reported to inhibit development of colon cancer. This protective role may be the result of …

Complex dietary sphingolipids such as sphingomyelin and glycosphingolipids have been
reported to inhibit the development of colon cancer. This protective role may be the result of …

Whereas some sphingolipids such as sphingoid bases and ceramide can mediate and
induce cell killing, other sphingolipids such as sphingosine 1-phosphate promote cell …

Sphingolipid metabolites regulate cell proliferation, migration, and stress responses.
Alterations in sphingolipid metabolism have been proposed to contribute to carcinogenesis …

Sphingolipids are membrane lipids that play important roles in the regulation of cell
functions and homeostasis. Alterations in their metabolism have been associated with …

The sphingolipid metabolites have emerged as a starting point for the development of novel
therapeutics for many diseases. However, details of the functions and mechanisms of …