Arecoline hydrobromide suppresses PI3K/AKT pathway in rheumatoid arthritis synovial fibroblasts and relieves collagen-induced arthritis in mice
J He, X Lin, X Wang, T Lin, S Lyu, X Gao, J Chen… - International …, 2023 - Elsevier
Objective This study investigated the effectiveness of arecoline hydrobromide (AH) on the
functions of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) and collagen …
functions of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) and collagen …
[HTML][HTML] Anti-inflammatory effects of Tabersonine in rheumatoid arthritis
RJ Zhang, SF Li, HJ Shi, JL Zhao… - Journal of …, 2022 - xiahepublishing.com
Methods To develop safer and more promising new treatments for arthritis, we tested the
biological activity of Tab against rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) …
biological activity of Tab against rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) …
Transcriptomic profiling revealed the role of apigenin-4′-O-α-L-rhamnoside in inhibiting the activation of rheumatoid arthritis fibroblast-like synoviocytes via MAPK …
D Cao, Q Fan, Z Li, M Chen, Y Jiang, R Lin, J Li… - Phytomedicine, 2022 - Elsevier
Background Activated fibroblast-like synoviocyte (FLS) played a significant role in the
pathogenesis and progression of rheumatoid arthritis (RA). Apigenin-4′-O-α-L-rhamnoside …
pathogenesis and progression of rheumatoid arthritis (RA). Apigenin-4′-O-α-L-rhamnoside …
Cinnamaldehyde attenuates the progression of rheumatoid arthritis through down-regulation of PI3K/AKT signaling pathway
X Li, Y Wang - Inflammation, 2020 - Springer
Cinnamaldehyde (CA), as an active compound isolated from the bark of Cinnamomum
cassia, has been reported to possess the anti-fungal, anti-bacterial, anti-inflammatory, anti …
cassia, has been reported to possess the anti-fungal, anti-bacterial, anti-inflammatory, anti …
Kurarinone attenuates collagen-induced arthritis in mice by inhibiting Th1/Th17 cell responses and oxidative stress
Kurarinone is a flavanone, extracted from Sophora flavescens Aiton, with multiple biological
effects. Here, we determine the therapeutic potential of kurarinone and elucidate the …
effects. Here, we determine the therapeutic potential of kurarinone and elucidate the …
Apoptotic Effect of Geniposide on Fibroblast-Like Synoviocytes in Rats with Adjuvant-Induced Arthritis via Inhibiting ERK Signal Pathway In Vitro
R Li, L Cai, W Tang, C Lei, C Hu, F Yu - Inflammation, 2016 - Springer
Stimulating fibroblast-like synoviocyte (FLS) apoptosis in rheumatoid arthritis (RA) is a
promising strategy for clinical treatment. Previous studies have confirmed that geniposide …
promising strategy for clinical treatment. Previous studies have confirmed that geniposide …
Inhibition of glycolysis ameliorate arthritis in adjuvant arthritis rats by inhibiting synoviocyte activation through AMPK/NF-кB pathway
Y Wang, H Xian, J Qi, F Wei, X Cheng, S Li… - Inflammation …, 2020 - Springer
Objective This study aimed to evaluate glycolysis inhibitor which can effectively ameliorate
arthritis by inhibiting synoviocyte activation through AMPK/NF-кB pathway in AA rats …
arthritis by inhibiting synoviocyte activation through AMPK/NF-кB pathway in AA rats …
Berberine inhibits RA-FLS cell proliferation and adhesion by regulating RAS/MAPK/FOXO/HIF-1 signal pathway in the treatment of rheumatoid arthritis
Z Li, M Chen, Z Wang, Q Fan, Z Lin, X Tao… - Bone & Joint …, 2023 - boneandjoint.org.uk
Aims Rheumatoid arthritis (RA) is a common chronic immune disease. Berberine, as its main
active ingredient, was also contained in a variety of medicinal plants such as Berberaceae …
active ingredient, was also contained in a variety of medicinal plants such as Berberaceae …
Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients Via NF-κB inhibition
QN Baito, HM Jaafar, TAM Mohammad - Cellular Immunology, 2023 - Elsevier
Rheumatoid Arthritis (RA) is a common autoimmune disease recognized by hyperplasia of
synoviocytes and chronic joint inflammation. Activation of fibroblast-like synoviocytes (FLSs) …
synoviocytes and chronic joint inflammation. Activation of fibroblast-like synoviocytes (FLSs) …
Paclitaxel inhibits synoviocyte migration and inflammatory mediator production in rheumatoid arthritis
X Chen, H Lin, J Chen, L Wu, J Zhu, Y Ye… - Frontiers in …, 2021 - frontiersin.org
Activated fibroblast-like synoviocytes (FLSs) play a crucial role in the pathogenesis and
progression of rheumatoid arthritis (RA). It is urgent to develop new drugs that can effectively …
progression of rheumatoid arthritis (RA). It is urgent to develop new drugs that can effectively …