Advances and progress in Chagas disease drug discovery

LG Ferreira, MT de Oliveira… - Current topics in …, 2016 - ingentaconnect.com
Chagas disease represents a serious burden for millions of people worldwide. Transmitted
by the protozoan parasite Trypanosoma cruzi, this neglected tropical disease causes more …

Chagas disease drug discovery: toward a new era

E Chatelain - Journal of biomolecular screening, 2015 - journals.sagepub.com
American trypanosomiasis, or Chagas disease, is the result of infection by the Trypanosoma
cruzi parasite. Endemic in Latin America where it is the major cause of death from …

[HTML][HTML] The translational challenge in Chagas disease drug development

JM Kratz, KR Gonçalves, L Romera… - Memorias do Instituto …, 2022 - SciELO Brasil
Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new …

Challenges in Chagas disease drug discovery: a review

R Paucar, E Moreno-Viguri… - Current Medicinal …, 2016 - ingentaconnect.com
Chagas disease or American trypanosomiasis is a neglected tropical disease caused by the
parasite Trypanosoma cruzi. Although the number of infected individuals has decreased …

Novel drug discovery for Chagas disease

CB Moraes, CH Franco - Expert opinion on drug discovery, 2016 - Taylor & Francis
Introduction: Chagas disease is a chronic infection associated with long-term morbidity.
Increased funding and advocacy for drug discovery for neglected diseases have prompted …

[HTML][HTML] Drug discovery for chagas disease: A viewpoint

JM Kratz - Acta tropica, 2019 - Elsevier
Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi. It is a significant public health problem, affecting millions of people …

[HTML][HTML] Challenges in Chagas disease drug development

AF Francisco, S Jayawardhana, F Olmo, MD Lewis… - Molecules, 2020 - mdpi.com
The protozoan parasite Trypanosoma cruzi causes Chagas disease, an important public
health problem throughout Latin America. Current therapeutic options are characterised by …

Report of the 2nd chagas drug discovery consortium meeting, held on 3 November 2010; Atlanta GA, USA

JM Bustamante, HJ Park, RL Tarleton… - Expert opinion on …, 2011 - Taylor & Francis
Chagas disease is an infectious disease with the highest impact in Latin America and a
growing worldwide problem. Chagas disease is the result of long-term, persistent infection …

Advances in preclinical approaches to Chagas disease drug discovery

F Villalta, G Rachakonda - Expert opinion on drug discovery, 2019 - Taylor & Francis
ABSTRACT Introduction: Chagas disease affects 8–10 million people worldwide, mainly in
Latin America. The current therapy for Chagas disease is limited to nifurtimox and …

Why hasn't there been more progress in new Chagas disease drug discovery?

AB Vermelho, GC Rodrigues… - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction: Chagas disease (CD) is a neglected disease caused by the protozoan parasite
Trypanosoma cruzi. In terms of novel drug discovery, there has been no progress since the …