Although the process of autophagy has been extensively studied, the mechanisms that
regulate it remain insufficiently understood. To identify novel autophagy regulators, we …

Autophagy is an evolutionarily conserved catabolic process by which cells degrade
intracellular proteins and organelles in the lysosomes. Canonical autophagy requires all …

Autophagy is an intracellular recycling and degradation pathway that depends on
membrane trafficking. Rab GTPases are central for autophagy but their regulation especially …

Autophagy has an important role in cellular homeostasis by degrading and recycling
cytotoxic components. Ubiquitination is known to target cargoes for autophagy; however, key …

Autophagy, a cellular self-eating mechanism, is important for maintaining cell survival and
tissue homeostasis in various stressed conditions. Although the molecular mechanism of …

ABSTRACT ULK1 (unc-51 like autophagy activating kinase 1) is the key mediator of
MTORC1 signaling to macroautophagy/autophagy. ULK1 functions as a protein complex by …

Autophagy maintains cellular homeostasis by degrading harmful or unnecessary
intracellular components. How the autophagy response is induced rapidly and transiently …

Autophagy is important in the basal or stress-induced clearance of bulk cytosol, damaged
organelles, pathogens and selected proteins by specific vesicles, the autophagosomes …

Macroautophagy/autophagy is a cellular process in which cytosolic contents are degraded
by lysosome in response to various stress conditions. Apart from its role in the maintenance …

Autophagy is a tightly regulated lysosomal degradation pathway for maintaining cellular
homeostasis and responding to stresses. Beclin 1 and its interacting proteins, including the …